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Titolo:
CHARACTERIZATION AND MODULATION OF ACUTE TOLERANCE TO NICOTINE IN MICE
Autore:
DAMAJ MI; WELCH SP; MARTIN BR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,BOX 980613 RICHMOND VA 23298
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 277, anno: 1996,
pagine: 454 - 461
SICI:
0022-3565(1996)277:1<454:CAMOAT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL CHROMAFFIN CELLS; INDUCED ANTINOCICEPTION; ACETYLCHOLINE-RECEPTOR; DESENSITIZATION; RATS; CALCIUM; ANTAGONISTS; SECRETION; AGONISTS; MORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Damaj et al., "CHARACTERIZATION AND MODULATION OF ACUTE TOLERANCE TO NICOTINE IN MICE", The Journal of pharmacology and experimental therapeutics, 277(1), 1996, pp. 454-461

Abstract

Acute tolerance to the effects of nicotine is believed to play an important role in the development and maintenance of dependence to this drug. The objective of this study was to investigate and characterize the development of acute tolerance to nicotine after systemic and intrathecal administrations. Acute tolerance developed to several centrallymediated pharmacological effects of nicotine after systemic (motor coordination, body temperature, antinociception) and intrathecal (antinociception) injection of the drug. The appearance and the magnitude of acute tolerance varied depending on the response measured. Developmentof acute tolerance to nicotine-induced hypothermia and motor impairment was blocked after intraperitoneal pretreatment with nimodipine. Similarly, an intrathecal injection of nimodipine blocked the developmentof acute tolerance to nicotine-induced antinociception. On the other hand, intrathecal administration of calcium and thapsigargin enhanced the acute tolerance to nicotine-induced antinociception. Characterization of the acute tolerance to nicotine in several animal models revealed time and dose dependencies that are consistent with receptor-mediated events. More importantly, acute tolerance was modulated by agents that influence cellular calcium homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:24:34