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Titolo:
BIOMARKER RESEARCH IN NEUROTOXICOLOGY - THE ROLE OF MECHANISTIC STUDIES TO BRIDGE THE GAP BETWEEN THE LABORATORY AND EPIDEMIOLOGIC INVESTIGATIONS
Autore:
COSTA LG;
Indirizzi:
UNIV WASHINGTON,DEPT ENVIRONM HLTH,4225 ROOSEVELT NE,100 SEATTLE WA 98105 FDN CLIN LAVORO,TOXICOL UNIT PAVIA ITALY
Titolo Testata:
Environmental health perspectives
, volume: 104, anno: 1996, supplemento:, 1
pagine: 55 - 67
SICI:
0091-6765(1996)104:<55:BRIN-T>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPATHY TARGET ESTERASE; DOPAMINE-BETA-HYDROXYLASE; OCCUPATIONALLY EXPOSED WORKERS; EPOXIDE METABOLITE GLYCIDAMIDE; INDUCED DELAYED NEUROTOXICITY; URINARY PORPHYRIN PROFILES; GAMMA-DIKETONE NEUROPATHY; CARBON-DISULFIDE EXPOSURE; ORGANO-PHOSPHORUS ESTERS; COVALENT CROSS-LINKING;
Keywords:
BIOMARKERS OF EFFECT; BIOMARKERS OF EXPOSURE; BIOMARKERS OF SUSCEPTIBILITY; BIOMONITORING; HEMOGLOBIN ADDUCTS; POLYMORPHISM; BLOOD CELLS; NEUROTRANSMISSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
187
Recensione:
Indirizzi per estratti:
Citazione:
L.G. Costa, "BIOMARKER RESEARCH IN NEUROTOXICOLOGY - THE ROLE OF MECHANISTIC STUDIES TO BRIDGE THE GAP BETWEEN THE LABORATORY AND EPIDEMIOLOGIC INVESTIGATIONS", Environmental health perspectives, 104, 1996, pp. 55-67

Abstract

There is an increasing interest in the development and validation of biomarkers for use in biochemical/molecular epidemiological studies. Though the area of neurotoxicology has received much attention in the past several years, it still lags behind with regard to the developmentof biomarkers, particularly those of health effects and susceptibility. This review discusses several aspects of biomarker research as it relates to neurotoxic compounds and focuses on selected agents (organophosphorus insecticides, styrene, n-hexane, carbon disulfide, acrylamide), which have been the subject of a number of investigations in animals and humans. While traditional biomonitoring approaches and novel techniques (e.g., hemoglobin adducts) provide several measurements for monitoring exposure to neurotoxic chemicals, potential markers of genetic susceptibility have been seldom investigated in a neurotoxicology context. Furthermore, the complexity of the nervous system, together with the multiplicity of end points and the limited knowledge of the exact mechanism(s) of action of neurotoxicants, has led to only limited advancements in the development of biomarkers for neurotoxic effects. Significant progress in this area will depend upon an increased understanding of the cellular, biochemical, and molecular targets directly involved in neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:30:36