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Titolo:
INTERACTION OF MU-OPIOID ANTAGONISTIC DRUGS ANTIEPILEPTICS
Autore:
FREY HH; SCHICHT S;
Indirizzi:
FREE UNIV BERLIN,SCH VET MED,DEPT PHARMACOL & TOXICOL,KOSERSTR 20 D-14195 BERLIN GERMANY
Titolo Testata:
Pharmacology & toxicology
fascicolo: 4, volume: 78, anno: 1996,
pagine: 264 - 268
SICI:
0901-9928(1996)78:4<264:IOMADA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-LIKE ANALGESICS; SEIZURES; MICE; PROCONVULSANT; INVOLVEMENT; THRESHOLD; NALOXONE; AGONIST; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
H.H. Frey e S. Schicht, "INTERACTION OF MU-OPIOID ANTAGONISTIC DRUGS ANTIEPILEPTICS", Pharmacology & toxicology, 78(4), 1996, pp. 264-268

Abstract

Interactions of the mu-opioid receptor antagonists, naloxone (0.3 and1 mg/kg), cyprodime and clocinnamox (3 and 10 mg/kg for both drugs) with phenytoin (7 mg/kg), phenobarbital (7 mg/kg), carbamazepine (10 mg/kg) and valproic acid (130 mg/kg) were investigated using the electroconvulsive threshold in mice as a model in order to elucidate a possible role of mu-receptor mediated reactions in the mechanism of action of antiepileptic drugs. All 3 mu-antagonists are devoid of an effect onthe electroconvulsive threshold. Pretreatment with the mu-antagonistsresulted partly in an increase of anticonvulsant action, partly in a decrease, and partly the pretreatment had no effect on the electroconvulsive threshold. The anticonvulsant effect of phenytoin was antagonized dose-dependently by naloxone, that of phenobarbital by the dose of 10 mg/kg of clocinnamox. A common denominator of the mu-antagonistic interactions with anticonvulsants cannot be found and the effects observed are therefore considered as ''unspecific''.

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Documento generato il 04/12/20 alle ore 22:16:55