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Titolo:
INHIBITORY EFFECTS AND TOXICITY OF GREEN TEA POLYPHENOLS FOR GASTROINTESTINAL CARCINOGENESIS
Autore:
YAMANE T; NAKATANI H; KIKUOKA N; MATSUMOTO H; IWATA Y; KITAO Y; OYA K; TAKAHASHI T;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT SURG 1,KAMIGYO KU,KAWARAMACHI HIROKOJI KYOTO 602 JAPAN
Titolo Testata:
Cancer
fascicolo: 8, volume: 77, anno: 1996, supplemento:, S
pagine: 1662 - 1667
SICI:
0008-543X(1996)77:8<1662:IEATOG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
(-)-EPIGALLOCATECHIN GALLATE; LUNG TUMORIGENESIS; ULTRAVIOLET-LIGHT; DRINKING-WATER; A/J MICE; CANCER; JAPAN; COLON; SKIN;
Keywords:
(-)-EPIGALLOCATECHIN GALLATE (EGCG); GREEN TEA EXTRACT (GTE); GASTROINTESTINAL CARCINOGENESIS; ORNITHINE DECARBOXYLASE (ODC) ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamane et al., "INHIBITORY EFFECTS AND TOXICITY OF GREEN TEA POLYPHENOLS FOR GASTROINTESTINAL CARCINOGENESIS", Cancer, 77(8), 1996, pp. 1662-1667

Abstract

BACKGROUND. Recently, an epidemiologic study showed a lower risk of gastrointestinal carcinogenesis in green tea drinkers. An experiment ontwo-stage skin carcinogenesis in mice showed that (-)-epigallocatechin gallate (EGCG), one of the main constituents of green tea, inhibitedtumor formation. METHODS. The inhibitory effects of EGCG and green tea extract (GTE) on N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced duodenal carcinogenesis in the mouse, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced carcinogenesis of the glandular stomach in the rat, and azoxymethane-induced colon carcinogenesis in the rat were examined. The toxicity of GTE was assessed experimentally and GTE was applied clinically in normal volunteers to determine the effective dose and to assess its harmful effects. RESULTS. EGCG and GTE inhibited chemical carcinogenesis of the gastrointestinal tract in rodents. Judging from the epidemiologic and experimental findings, it was determined that 1 g per day of GTE might be an effective dose. GTE was not toxic and no harmful effect was found during its clinical use. CONCLUSIONS. Thesefindings suggest that EGCG and GTE are useful in preventing gastrointestinal carcinogenesis, and the clinical usefulness of GTE, which has no harmful effects and is inexpensive, should be studied further. (C) 1996 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:44:15