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Titolo:
IMMUNOLOGICAL, GENETIC, AND MICROBIOLOGICAL STUDY OF FAMILY MEMBERS MANIFESTING EARLY-ONSET PERIODONTITIS
Autore:
NAKAGAWA M; KURIHARA H; NISHIMURA F; ISOSHIMA O; ARAI H; SAWADA K; NAGAI A; MURAYAMA Y;
Indirizzi:
OKAYAMA UNIV,SCH DENT,DEPT PERIODONTOL & ENDODONTOL,2-5-1 SHIKATA CHOOKAYAMA 700 JAPAN OKAYAMA UNIV,SCH DENT,DEPT PERIODONTOL & ENDODONTOL OKAYAMA 700 JAPAN
Titolo Testata:
Journal of periodontology
fascicolo: 3, volume: 67, anno: 1996,
pagine: 254 - 263
SICI:
0022-3492(1996)67:3<254:IGAMSO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED JUVENILE PERIODONTITIS; TUMOR NECROSIS FACTOR; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; YOUNG-ADULTS; HLA-ANTIGENS; PREPUBERTAL PERIODONTITIS; MONONUCLEAR-CELLS; HIGH PREVALENCE; HOST RESPONSES; SERUM ANTIBODY;
Keywords:
NEUTROPHILS; PERIODONTITIS, EARLY ONSET IMMUNOLOGY; PERIODONTITIS, JUVENILE IMMUNOLOGY; HOST-PARASITE RELATIONS; PERIODONTAL POCKETS MICROBIOLOGY; HISTOCOMPATIBILITY ANTIGENS; IGG; LYMPHOCYTES; PERIODONTITIS, EARLY ONSET MICROBIOLOGY; PERIODONTITIS JUVENILE MICROBIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakagawa et al., "IMMUNOLOGICAL, GENETIC, AND MICROBIOLOGICAL STUDY OF FAMILY MEMBERS MANIFESTING EARLY-ONSET PERIODONTITIS", Journal of periodontology, 67(3), 1996, pp. 254-263

Abstract

FROM THE STANDPOINT OF HOST-PARASITE INTERACTIONS, family studies help us understand the host defensive factors and the molecular mechanisms involved in the periodontal immune response. in this study, we report the immunological profile of host-defensive functions, human leukocyte antigen (HLA) phenotypes, and the microflora of a mother (rapidly progressive periodontitis), an older son (periodontally healthy), a younger son (localized juvenile periodontitis), and a daughter (localizedjuvenile periodontitis). We examined the peripheral neutrophil functions, phenotypic and functional analysis of peripheral lymphocytes, serum immunoglobulin G (IgG) antibody titers against periodontopathic bacteria, serological type of HLA class TI antigens, and bacterial flora in all periodontal pockets. The results showed that Actinobacillus actinomycetemcomitans was dominant in the pockets of all subjects. The mother and two sons showed a depressed neutrophil chemotaxis to N-formyl-methionyl-leucyl-phenylalanine. All subjects except the older son exhibited low T4/T8 ratios. The mother and daughter had raised levels of IgG titers to Porphyromonas gingivalis, All subjects had HLA phenotypes of DRw52 and DQ1 in common. We found that the family members had similar disorders in certain defensive functions. This family has been a model for our understanding of the host defensive factors in the development of early-onset periodontitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:37:09