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Titolo:
THE EFFECTS OF GUIDED TISSUE REGENERATION AND FIXATION TECHNIQUE ON OSSEOUS WOUND-HEALING IN RABBIT ZYGOMATIC ARCH OSTEOTOMIES
Autore:
MOONEY MP; MUNDELL RD; STETZER K; OCHS MW; MILCH EA; BUCKLEY MJ; SIEGEL MI;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAT & HISTOL,SCH DENT MED,619 SALK HALL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ANTHROPOL,SCH DENT MED PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PLAST SURG,SCH DENT MED PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ORTHODONT,SCH DENT MED PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ORAL & MAXILLOFACIAL SURG,SCH DENT MED PITTSBURGH PA 15260
Titolo Testata:
The Journal of craniofacial surgery
fascicolo: 1, volume: 7, anno: 1996,
pagine: 46 - 53
SICI:
1049-2275(1996)7:1<46:TEOGTR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTACHMENT FORMATION; COLLAGEN MEMBRANES; NONRIGID FIXATION; MACACA-MULATTA; BONE DEFECTS; OSTEOPROMOTION; ADVANCEMENT; MAXILLARY; MIGRATION; GROWTH;
Keywords:
GUIDED TISSUE REGENERATION; COLLAGEN MEMBRANE; RIGID/NONRIGID FIXATION; MICROPLATES; OSTEOSYNTHETIC WIRES; NEW ZEALAND WHITE RABBITS; ZYGOMATIC ARCH; BONE REGENERATION; CRANIOFACIAL SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Mooney et al., "THE EFFECTS OF GUIDED TISSUE REGENERATION AND FIXATION TECHNIQUE ON OSSEOUS WOUND-HEALING IN RABBIT ZYGOMATIC ARCH OSTEOTOMIES", The Journal of craniofacial surgery, 7(1), 1996, pp. 46-53

Abstract

The development of fibrous nonunions after craniofacial surgery is thought to result from an interaction of biomechanical stress and the differential migration of various tissue types into the wound site during healing. The present study is designed to test this hypothesis through the manipulation of guided tissue regeneration and osteotomy fixation techniques in an experimental rabbit model. Bilateral, critical size (5 mm) vertical osteotomies (n = 32) were produced in the zygomatic arches of eight adult rabbits. The mobile bony segments were fixed rigidly or nonrigidly using bone microplates and screws or osteosyntheticwires. The defects were then covered with a resorbable collagen membrane or left uncovered. The rabbits were followed for 4 weeks with serial dorsoventral cephalographs and the zygomatic arches harvested for histological analysis. Cephalometric results revealed significantly (p < 0.001) increased bone growth in the margins of the defects covered with the collagen membrane; however, no significant (p > 0.05) differences were noted between fixation techniques. Histological analysis revealed that defects fixed rigidly and covered by the membrane showed themost rapid and organized osseous wound healing, followed by the defects that were fixed nonrigidly and membrane covered. The defects not covered by the collagen membrane showed invasion by fibroblasts resulting in fibrous nonunions. These results demonstrate the efficacy of guided tissue regeneration with a resorbable collagen membrane in preventing fibrous tissue ingrowth in large bony defects. The addition of rigid fixation at a potentially mobile site appeared to enhance bony trabecular organization but not the osteogenic rate in this rabbit model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 05:38:02