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Titolo:
DYNAMICS OF GAMETIC DISEQUILIBRIA BETWEEN LOCI LINKED TO CHROMOSOME INVERSIONS - THE RECOMBINATION REDISTRIBUTING EFFECT OF INVERSIONS
Autore:
NAVARRO A; BETRAN E; ZAPATA C; RUIZ A;
Indirizzi:
UNIV AUTONOMA BARCELONA,DEPT GENET & MICROBIOL E-08193 BARCELONA SPAIN UNIV SANTIAGO DE COMPOSTELA,DEPT BIOL FUNDAMENTAL E-15706 SANTIAGO SPAIN
Titolo Testata:
Genetical Research
fascicolo: 1, volume: 67, anno: 1996,
pagine: 67 - 76
SICI:
0016-6723(1996)67:1<67:DOGDBL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE DISEQUILIBRIUM; DROSOPHILA-SUBOBSCURA; GENETIC COADAPTATION; NATURAL-POPULATION; ALLOZYME LOCI; POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Navarro et al., "DYNAMICS OF GAMETIC DISEQUILIBRIA BETWEEN LOCI LINKED TO CHROMOSOME INVERSIONS - THE RECOMBINATION REDISTRIBUTING EFFECT OF INVERSIONS", Genetical Research, 67(1), 1996, pp. 67-76

Abstract

The total gametic disequilibrium between two loci linked to polymorphic inversions can be partitioned into two types of components: within and between chromosome arrangements. The within components depend on the gametic disequilibrium within each chromosome arrangement. The between components depend on the locus-inversion disequilibria. This partitioning has practical applications and is indispensable for studying the dynamics of these systems because inversions greatly reduce recombination in the heterokaryotypes while allowing free, and sometimes different, recombination in each of the homokaryotypes. We provide equations for the per generation change of the various disequilibria for systems with two and three chromosome arrangements, and the general recursive equations predicting the disequilibria after any number of generations for the case of two arrangements, Simulation studies were carriedout using different values of the recombination parameters and all possible initial conditions. The results show a complex convergence to linkage equilibrium in inversion systems. The various disequilibria canhave local maxima and minima while approaching equilibrium and, moreover, their dynamics cannot be described, in general, using a single parameter, i.e. an effective recombination rate. We conclude that the effects of inversions on gametic disequilibria must be carefully considered when dealing with disequilibria in inversion systems. The formulaeprovided in this paper can be used for such purpose.

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Documento generato il 03/12/20 alle ore 21:53:12