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Titolo:
NEURONAL ARGYROPHILIA AND PHOSPHORYLATED NEUROFILAMENT ACCUMULATION SECONDARY TO DEAFFERENTATION
Autore:
TORACK RM; ROTH KA; MILLER JW;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL ST LOUIS MO 63110
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 4, volume: 55, anno: 1996,
pagine: 466 - 470
SICI:
0022-3069(1996)55:4<466:NAAPNA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; MICROTUBULE-BINDING; DENTATE GYRUS; TAU-PROTEIN; RAT; IMMUNOREACTIVITY; ANTIBODIES; LESIONS;
Keywords:
ARGYROPHILIA; DEAFFERENTATION; NEUROFIBRILLARY TANGLES; PHOSPHORYLATED PROTEINS; PRE-TANGLE STATE; PYRAMIDAL NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Torack et al., "NEURONAL ARGYROPHILIA AND PHOSPHORYLATED NEUROFILAMENT ACCUMULATION SECONDARY TO DEAFFERENTATION", Journal of neuropathology and experimental neurology, 55(4), 1996, pp. 466-470

Abstract

This work tests the hypothesis that deafferentation caused by experimental brain lesions leads to the appearance of perikaryal argyrophiliaand the accumulation of phosphorylated cytoskeletal proteins which are potential precursors for neurofibrillary tangle formation. Destructive lesions of the ventral tegmental area, the septum of the medial forebrain and the entorhinal cortex, when combined with systemic administration of a D-l dopamine receptor antagonist, produced transsynaptic changes in neurons of the hippocampal formation and in the midbrain. Abnormally phosphorylated neurofilament protein was demonstrated immunohistochemically in the cytoplasm of mesencephalic pyramidal neurons, particularly in the red nucleus. These same neurons also developed cytoplasmic argyrophilia in Bielschowsky histologic preparations. Although distinct neurofibrillary tangles were nor produced with this paradigm,both the protein immunoreactivity and argyrophilia were arranged in cytoplasmic linear arrays. The structural changes induced in this experimental model may be an important preliminary stage for neurofibrillary tangle formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:34:31