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Titolo:
SYNTHESIS OF A RADIOTRACER FOR STUDYING NICOTINIC ACETYLCHOLINE-RECEPTORS - (+ F-18]FLUORO-5-PYRIDYL)-7-AZABICYCLO[2,2.1]HEPTANE/
Autore:
HORTI A; RAVERT HT; LONDON ED; DANNALS RF;
Indirizzi:
JOHNS HOPKINS MED INST,DIV NUCL MED,615 N WOLFE ST,ROOM 2001 BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DIV NUCL MED BALTIMORE MD 21205 NIDA,INTRAMURAL RES PROGRAM,NEUROIMAGING & DRUG ACT SECT BALTIMORE MD21224 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT BALTIMORE MD 21201 JOHNS HOPKINS MED INST,DIV RADIAT HLTH SCI BALTIMORE MD 21205
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 4, volume: 38, anno: 1996,
pagine: 355 - 365
SICI:
0362-4803(1996)38:4<355:SOARFS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; RAT-BRAIN MEMBRANES; BINDING-SITES; CHOLINERGIC RECEPTORS; ALZHEIMERS-DISEASE; CEREBRAL-CORTEX; MOUSE-BRAIN;
Keywords:
RADIOTRACER; EPIBATIDINE; F-18; FLUORINATION; HALOGEN-EXCHANGE; NICOTINIC RECEPTORS; ACETYLCHOLINE; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A. Horti et al., "SYNTHESIS OF A RADIOTRACER FOR STUDYING NICOTINIC ACETYLCHOLINE-RECEPTORS - (+ F-18]FLUORO-5-PYRIDYL)-7-AZABICYCLO[2,2.1]HEPTANE/", Journal of labelled compounds & radiopharmaceuticals, 38(4), 1996, pp. 355-365

Abstract

The radiochemical synthesis of o-2-(2-[F-18]fluoro-5-pyridyl)-7-azabicyclo[2.2.1] heptane ([F-18]1) was accomplished by Kryptofix(R) 222 assisted nucleophilic no-carrier-added [F-18]fluorination of +/-)-exo-2-(2-bromo-5-pyridyl)-7-azabicyclo[2.2.1] heptane (3a). The average radiochemical yield of the final product was 10% and the average specific activity was greater than >2000 mCi/mu mol, calculated at end-of-synthesis. The stable fluorine ligand ([F-19]1) was prepared by Kryptofix(R) 222 assisted nucleophilic fluorination of (2-bromo-5-pyridyl)-7-methoxycarbonyl-7-azabicyclo [2.2.1]heptane (3b) followed by acid deprotection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:11:59