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Titolo:
ASSOCIATION OF FIBRINOGEN AND COAGULATION-FACTOR-VII AND COAGULATION-FACTOR-VIII WITH CARDIOVASCULAR RISK-FACTORS IN THE ELDERLY - THE CARDIOVASCULAR HEALTH STUDY
Autore:
CUSHMAN M; YANEZ D; PSATY BM; FRIED LP; HEISS G; LEE M; POLAK JF; SAVAGE PJ; TRACY RP;
Indirizzi:
COORDINATING CTR,CARDIOVASC HLTH STUDY,CENTURY SQ,1501 4TH AVE,SUITE 2025 SEATTLE WA 98101 UNIV VERMONT,DEPT PATHOL & MED BURLINGTON VT 00000 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 JOHNS HOPKINS UNIV,DEPT MED BALTIMORE MD 00000 JOHNS HOPKINS UNIV,DEPT EPIDEMIOL BALTIMORE MD 00000 UNIV N CAROLINA,DEPT EPIDEMIOL CHAPEL HILL NC 00000 UNIV CALIF DAVIS,DEPT MED DAVIS CA 95616 BRIGHAM & WOMENS HOSP,DEPT RADIOL BOSTON MA 02115 NHLBI,EPIDEMIOL & BIOMETRY PROGRAM BETHESDA MD 20892 UNIV VERMONT,DEPT PATHOL BURLINGTON VT 05405 UNIV VERMONT,DEPT BIOCHEM BURLINGTON VT 05405
Titolo Testata:
American journal of epidemiology
fascicolo: 7, volume: 143, anno: 1996,
pagine: 665 - 676
SICI:
0002-9262(1996)143:7<665:AOFACA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL ESTROGEN THERAPY; ISCHEMIC-HEART-DISEASE; VON-WILLEBRAND-FACTOR; PLASMA-FIBRINOGEN; INDUSTRIAL-POPULATION; HEMOSTATIC FUNCTION; BASELINE DATA; ATHEROSCLEROSIS; CHOLESTEROL; MENOPAUSE;
Keywords:
AGED; BLOOD COAGULATION FACTORS; CARDIOVASCULAR DISEASE; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
M. Cushman et al., "ASSOCIATION OF FIBRINOGEN AND COAGULATION-FACTOR-VII AND COAGULATION-FACTOR-VIII WITH CARDIOVASCULAR RISK-FACTORS IN THE ELDERLY - THE CARDIOVASCULAR HEALTH STUDY", American journal of epidemiology, 143(7), 1996, pp. 665-676

Abstract

The cross-sectional correlates of three hemostatic factors-fibrinogen, factor VII, and factor VIII-were examined in the Cardiovascular Health Study, a population-based cohort study of 5,201 subjects over age 65 years. Subjects were recruited in 1989-1990 in Forsyth County, NorthCarolina; Sacramento County, California; Washington County, Maryland;and Pittsburgh, Pennsylvania. In multivariate linear regression models, cardiac risk factors significantly associated with fibrinogen were current smoking, race, lipids, and white blood count. In women, alcohol use, obesity, physical activity, and insulin level were also significant, while in men hypertension was correlated. The significant correlates of factor VII were lipids and white blood count in men and estrogen use, alcohol use, race, lipids, insulin level, white blood count, and obesity in women. The independent correlates of factor VIII were insulin, glucose, and race in both sexes; low density lipoprotein cholesterol, white blood count, and diuretic use in men; and alcohol use in women. In multivariate models, factors known to be modifiable risk factors for cardiovascular disease accounted for more of the population variance of these hemostatic factors in women than in men, especially for factor VII. The hemostatic factors may mediate some effects of riskfactors on disease, and this should be considered in longitudinal studies.

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Documento generato il 25/11/20 alle ore 15:47:51