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Titolo:
MEDIATORS OF INFLAMMATION IN CHRONIC INFLAMMATORY BOWEL-DISEASE
Autore:
NIELSEN OH; RASKMADSEN J;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT MED GASTROENTEROL 261,KETTEGARD ALLE 30 DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT MED GASTROENTEROL 261 DK-2650 HVIDOVRE DENMARK DEPT MED GASTROENTEROL DK-2730 HERLEV DENMARK
Titolo Testata:
Scandinavian journal of gastroenterology
, volume: 31, anno: 1996, supplemento:, 216
pagine: 149 - 159
SICI:
0036-5521(1996)31:<149:MOIICI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EQUILIBRIUM INVIVO DIALYSIS; PLATELET-ACTIVATING FACTOR; ULCERATIVE-COLITIS; 5-AMINOSALICYLIC ACID; RADICAL SCAVENGER; HUMAN-NEUTROPHILS; IMMUNE; COMPLEMENT; INTERLEUKINS; EICOSANOIDS;
Keywords:
CHEMOTACTIC FACTORS; COLITIS; ULCERATIVE; COMPLEMENT; CROHN DISEASE; CYTOKINES; EICOSANOIDS; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY MEDIATORS; LEUKOTRIENES; NEUROPEPTIDES; NITRIC OXIDE; PLATELET ACTIVATING FACTOR; PROSTAGLANDINS; REACTIVE OXYGEN SPECIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
O.H. Nielsen e J. Raskmadsen, "MEDIATORS OF INFLAMMATION IN CHRONIC INFLAMMATORY BOWEL-DISEASE", Scandinavian journal of gastroenterology, 31, 1996, pp. 149-159

Abstract

A distinguishing feature of inflammatory bowel disease (IBD) is its apparently spontaneous, chronic relapsing course. Despite extensive research over several decades the etiology of IBD remains unknown, but evidence has accumulated to suggest that the mucosal inflammatory response may be caused by (i) a defective mucosal barrier function resultingin an abnormally increased exposure to luminal antigens and toxins, (ii) an appropriate immunologic response to an unusual infection, antigen or toxin, or (iii) an inappropriate immunological response to ubiquitous antigens or stimuli. In recent years, the identification of established and potential mediators of inflammation has expanded to include eicosanoids, platelet activating factor, biogenic amines, kinins, complement-derived peptides, chemotactic peptides, cytokines, neuropeptides, and reactive metabolites of oxygen and nitrogen. Thus, the study of the inflammatory process has become ever more complex. Until the predisposing and trigger factors have been identified the achievement ofa more rational and effective approach to therapy in IBD relies on interruption of the mechanisms responsible for excess mediator formation. As summarized in this review on the role of soluble mediators of inflammation, several Danish gastroenterologists have been profoundly engaged in basic and clinical research in the past 25 years to place somepieces of the confusing puzzle of IBD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:38:41