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Titolo:
NATURAL-HISTORY AND PROGNOSTIC FACTORS IN 305 SWEDISH PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS
Autore:
BROOME U; OLSSON R; LOOF L; BODEMAR G; HULTCRANTZ R; DANIELSSON A; PRYTZ H; SANDBERGGERTZEN H; WALLERSTEDT S; LINDBERG G;
Indirizzi:
HUDDINGE UNIV HOSP,DEPT GASTROENTEROL & HEPATOL,K63 S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPT MED S-10401 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT MED S-10401 STOCKHOLM SWEDEN SAHLGRENS UNIV HOSP,DEPT MED GOTHENBURG SWEDEN ACAD HOSP,DEPT MED UPPSALA SWEDEN UNIV HOSP LINKOPING SWEDEN UNIV HOSP UMEA SWEDEN UNIV HOSP LUND SWEDEN REG HOSP OREBRO SWEDEN OSTA HOSP GOTHENBURG SWEDEN
Titolo Testata:
Gut
fascicolo: 4, volume: 38, anno: 1996,
pagine: 610 - 615
SICI:
0017-5749(1996)38:4<610:NAPFI3>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; LIVER-TRANSPLANTATION; ASSOCIATION; CHOLANGIOCARCINOMA; HLA-DRW52A; FEATURES; DISEASE;
Keywords:
ULCERATIVE COLITIS; PROGNOSTIC MODELS; LIVER TRANSPLANTATION; CHOLANGIOCARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
U. Broome et al., "NATURAL-HISTORY AND PROGNOSTIC FACTORS IN 305 SWEDISH PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS", Gut, 38(4), 1996, pp. 610-615

Abstract

Background/Aims-The course primary sclerosing cholangitis (PSC) is highly variable and unpredictable. This study describes the natural history and outcome of PSC. These data were used to construct a prognosticmodel for patients with PSC. Methods-A total of 305 Swedish patients with PSC were studied. The median follow up time was 63 (1-194) monthsand all patients could be traced for follow up. Some 79 patients diedor had a liver transplant. The prognostic significance of clinical, biochemical, and histological findings at the time of diagnosis were evaluated using multivariate analysis. Results-The estimated median survival from time of diagnosis to death or liver transplantation was 12 years. Cholangiocarcinoma was found in 24 (8%) of the patients and 134 (44%) of the patients were asymptomatic at the time of diagnosis. The estimated survival rate was significantly higher in the asymptomatic group (p<0.001). However, 29 (22%) of the asymptomatic patients became symptomatic during the study period. It was found that age, serum bilirubin concentration, and histological stage at the time of diagnosis were independent predictors of a bad prognosis. These variables were used to construct a prognostic model. Conclusions-This prognostic model developed from a large homogeneous population of PSC patients should be of value for the timing of transplantation and patient counselling in PSC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:44:49