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Titolo:
EFFECTS OF OVARIECTOMY ON MECHANICAL-PROPERTIES AND COLLAGEN CONTENT IN RABBIT LOWER URINARY-TRACT SMOOTH-MUSCLE
Autore:
PERSSON K; SVANE D; GLAVIND B; UVELIUS B; FORMAN A; ANDERSSON KE;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN AARHUS UNIV HOSP,DEPT OBSTET & GYNECOL DK-8000 AARHUS DENMARK AARHUS UNIV HOSP,DEPT SURG GASTROENTEROL DK-8000 AARHUS DENMARK
Titolo Testata:
Scandinavian journal of urology and nephrology
fascicolo: 1, volume: 30, anno: 1996,
pagine: 7 - 14
SICI:
0036-5599(1996)30:1<7:EOOOMA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
URETHRAL PRESSURE PROFILE; FEMALE RABBIT; STRESS-INCONTINENCE; OUTLET OBSTRUCTION; PASSIVE PROPERTIES; RECEPTOR DENSITY; BLADDER FUNCTION; FETAL BLADDER; ESTROGEN; RESPONSES;
Keywords:
COLLAGEN; ESTROGEN; SMOOTH MUSCLE; URINARY TRACT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
K. Persson et al., "EFFECTS OF OVARIECTOMY ON MECHANICAL-PROPERTIES AND COLLAGEN CONTENT IN RABBIT LOWER URINARY-TRACT SMOOTH-MUSCLE", Scandinavian journal of urology and nephrology, 30(1), 1996, pp. 7-14

Abstract

Fourteen female rabbits underwent ovariectomy or were sham-operated six weeks before investigation. Detrusor and urethral strips (longitudinal and circular urethral muscle fibers were studied separately) were prepared and length-tension relations studied in organ baths experiments. In addition, the specimens were examined for collagen content. Maximal active tension in the detrusor; longitudinal and circular urethral preparations, determined as the response to K+ (124 mM), was reachedwhen the length of the strips was 178 +/- 8% (n = 7), 153 +/- 9% (n =5), and 127 +/- 5% (n = 7) of the resting length, respectively. Ovariectomy did not alter the length for development of maximal active tension. In detrusor strips, ovariectomy caused a significant increase in maximal active tension from 39 +/- 7 mN (sham-operated rabbits) to 79 /- 11 mN (p < 0.01), despite an unchanged relative amount of smooth muscle. The maximal active tension produced in the urethra was lower (15-25 mN) than in the detrusor, and not significantly affected by ovariectomy. Approximately 40% of the dry defatted tissue weight of the detrusor consisted of collagen, whereas corresponding value in the urethra was 50-60%. Ovariectomy had no effect on tissue collagen concentrations. In conclusion, ovariectomy for six weeks did not affect the passive mechanical Properties or the collagen concentration in rabbit lowerurinary tract smooth muscle, but increased the responsiveness of the detrusor muscle to K+ (124 mM).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:30:27