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Titolo:
EFFECT OF A HIGH-PROTEIN MEAL ON GABAPENTIN PHARMACOKINETICS
Autore:
GIDAL BE; MALY MM; BUDDE J; LENSMEYER GL; PITTERLE ME; JONES JC;
Indirizzi:
UNIV WISCONSIN,SCH PHARM,425 N CHARTER ST MADISON WI 53706 UNIV WISCONSIN,DEPT NEUROL MADISON WI 53706 UNIV WISCONSIN,DEPT LAB MED MADISON WI 53706
Titolo Testata:
Epilepsy research
fascicolo: 1, volume: 23, anno: 1996,
pagine: 71 - 76
SICI:
0920-1211(1996)23:1<71:EOAHMO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACIDS; TRANSPORT; PLASMA; BRAIN; MECHANISMS; ABSORPTION; DIET;
Keywords:
GABAPENTIN; PHARMACOKINETICS; DRUG-NUTRIENT INTERACTION; L-AMINO ACID TRANSPORT SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
B.E. Gidal et al., "EFFECT OF A HIGH-PROTEIN MEAL ON GABAPENTIN PHARMACOKINETICS", Epilepsy research, 23(1), 1996, pp. 71-76

Abstract

The anticonvulsant, gabapentin is transported across biological membranes via the L-amino acid transport system (System-L). Absorption of gabapentin is saturable, and in-vitro data have previously demonstratedthat both L-leucine and L-phenylalanine may compete with the intestinal transport of gabapentin. The purpose of this study therefore was todetermine whether a high-protein meal would interfere with gabapentinabsorption. Ten healthy volunteers received in a randomized, cross-over design, a single 600-mg dose of gabapentin in the fasting state andafter a high-protein meal consisting of 80 gm total protein (4.1 g phenylalanine, 8.2 g leucine and 4.2 g isoleucine), 52 g carbohydrate, and 9 g fat. Plasma gabapentin concentrations were measured by HPLC at baseline, 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12, 24,30 h. Calculated pharmacokinetic parameters included C-max, T-max, AUC and T-1/2. In addition, a pharmacodynamic assessment (using visual analog scales) of gabapentin-related adverse effects was performed at 2h post drug ingestion and was compared between study phases. Statistical analysis included Student's t-test for paired data, with significance assigned at P < 0.05. C-max was significantly increased by 36% (3.87 +/- 1.15 vs 5.28 +/- .97 mu g/ml, P = 0.002), and T-max tended to be shorter (3.9 +/- 1.8 vs 2.8 +/- .35 h, P = 0.10), after the high-protein meal. Although AUC was increased by 11%, this did not achieve statistical significance. Despite significantly higher plasma concentrations at 2 h, subjects reported significantly fewer adverse effects after the high-protein meal. Potential mechanisms to explain these unexpected findings may be that the large amino acid load delivered with the high-protein meal enhanced gabapentin absorption via trans-stimulation, the process by which acutely increased intestinal luminal amino acidconcentrations result in an acute up regulation in System-L activity. Conversely, the decrease in perceived adverse CNS effects of gabapentin following the high-protein meal may reflect CNS competition for System-L transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:59:55