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Titolo:
EFFECTS OF THE UNCOMPETITIVE NMDA RECEPTOR ANTAGONIST MEMANTINE ON HIPPOCAMPAL LONG-TERM POTENTIATION, SHORT-TERM EXPLORATORY MODULATION AND SPATIAL MEMORY IN AWAKE, FREELY MOVING RATS
Autore:
BARNES CA; DANYSZ W; PARSONS CG;
Indirizzi:
UNIV ARIZONA,ARIZONA RES LABS,DIV NEURAL SYST MEMORY & AGING TUCSON AZ 85724 UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85724 UNIV ARIZONA,DEPT NEUROL TUCSON AZ 85724 MERZ & CO,DEPT PHARMACOL D-60318 FRANKFURT GERMANY
Titolo Testata:
European journal of neuroscience
fascicolo: 3, volume: 8, anno: 1996,
pagine: 565 - 571
SICI:
0953-816X(1996)8:3<565:EOTUNR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; TIME COURSE; TRANSMISSION; RESPONSES; MK-801; ACQUISITION; INFORMATION; ENHANCEMENT; HABITUATION; PERFORMANCE;
Keywords:
MORRIS MAZE; FASCIA DENTATA; CHRONIC; ORAL ADMINISTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Barnes et al., "EFFECTS OF THE UNCOMPETITIVE NMDA RECEPTOR ANTAGONIST MEMANTINE ON HIPPOCAMPAL LONG-TERM POTENTIATION, SHORT-TERM EXPLORATORY MODULATION AND SPATIAL MEMORY IN AWAKE, FREELY MOVING RATS", European journal of neuroscience, 8(3), 1996, pp. 565-571

Abstract

Chronic treatment of adult male F-344 rats (9-12 months old) with therapeutically relevant doses of memantine (30 mg/kg/day in chow for >8 weeks) increased the maintenance of long-term potentiation of field excitatory postsynaptic potentials from perforant path-granule cell hippocampal synapses recorded in the fascia dentata in vivo. In contrast, there was no effect of memantine on baseline synaptic responses or population spikes. Likewise, short-term exploratory modulation of these hippocampal evoked responses was not different between memantine-treated and control rats. Both groups of rats were able to learn the spatialversion of the Morris water task equally well, but the memantine-treated group showed a strong tendency to show more selective spatial search patterns in the training quadrant of the water pool during a final probe trial. As such, these studies provide the first electrophysiological evidence that memantine can increase the durability of synaptic plasticity and provide preclinical confirmation of the cognitive improvement seen with memantine in the treatment of demented patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:04:22