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Titolo:
BONE-MARROW DOSIMETRY - REGIONAL VARIABILITY OF MARROW-LOCALIZING ANTIBODY
Autore:
SGOUROS G; JUREIDINI IM; SCOTT AM; GRAHAM MC; LARSON SM; SCHEINBERG DA;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT RADIOL,NUCL MED SERV,DEPT MED PHYS,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT MED,LEUKEMIA SERV NEW YORK NY 10021
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 4, volume: 37, anno: 1996,
pagine: 695 - 698
SICI:
0161-5505(1996)37:4<695:BD-RVO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOGENOUS LEUKEMIA; MONOCLONAL-ANTIBODIES; RADIOIMMUNOTHERAPY; TISSUE; I-131; M195; IRRADIATION; RADIATION; TRIAL;
Keywords:
RADIOIMMUNOTHERAPY; BONE MARROW DOSIMETRY; LEUKEMIA; IODINE-123-HUM195;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G. Sgouros et al., "BONE-MARROW DOSIMETRY - REGIONAL VARIABILITY OF MARROW-LOCALIZING ANTIBODY", The Journal of nuclear medicine, 37(4), 1996, pp. 695-698

Abstract

In radiolabeled antibody therapy, imaging and biopsy-based methods are used to estimate marrow activity concentration when the administeredantibody localizes to the marrow. Absorbed dose estimates obtained using such measurements may be subject to large variability due to the potential for regional differences in marrow activity concentration, This variability was examined in ten patients with leukemia after administration of I-131-labeled HuM195 antibody, Methods: Regions of interest were drawn around the head and neck of the humerus and femur (both sides) and around lumbar vertebra 3 (L3) and 4 (L4) on a series of planar images collected at multiple times postadministration of the antibody, A single exponential fit to each attenuation-corrected, time-activity curve was obtained to estimate clearance half-life and the back-extrapolated percent injected activity. Results: The activity concentration in the femoral head and neck (mean and s.d. = 0.04 +/- 0.02% ID/g)was not significantly different than that measured in L3 and L4 (0.06+/- 0.02% ID/g) but was significantly lower than the concentrations measured in the humeral head and neck regions (0.07 +/- 0.03% ID/g, p <0.05), Although half-life estimates differing by more than a factor of 2 were observed among different regions for individual patients, no systematic difference was observed in half-life between regions overall, S-factors were used for individual marrow regions to determine the mean absorbed dose to marrow in the femoral and humeral heads and the lumbar vertebrae (L3 and L4) which were 0.66 +/- 0.3, 1.0 +/- 0.3 and 2.2 +/- 0.5 mGy/MBq (2.4, 3.8 and 8.3 rad/mCi), respectively, Conclusion: A single value is generally quoted for the absorbed dose deliveredto the red marrow following marrow-localizing radiolabeled antibody administration, These results suggest that the regional marrow dose maydiffer significantly from the mean.

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Documento generato il 11/07/20 alle ore 16:29:49