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Titolo:
EFFECT OF ACUTE AND CHRONIC TREATMENT WITH TRIIODOTHYRONINE ON SEROTONIN LEVELS AND SEROTONERGIC RECEPTOR SUBTYPES IN THE RAT-BRAIN
Autore:
SANDRINI M; VITALE G; VERGONI AV; OTTANI A; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
Life sciences
fascicolo: 18, volume: 58, anno: 1996,
pagine: 1551 - 1559
SICI:
0024-3205(1996)58:18<1551:EOAACT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A RECEPTORS; THYROID-HORMONES; HEAD-TWITCH; MICE; DEPRESSION; IMIPRAMINE; AGONIST; T3; ANTIDEPRESSANTS; HYPOTHYROIDISM;
Keywords:
TRIIODOTHYRONINE; 5-HT; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Sandrini et al., "EFFECT OF ACUTE AND CHRONIC TREATMENT WITH TRIIODOTHYRONINE ON SEROTONIN LEVELS AND SEROTONERGIC RECEPTOR SUBTYPES IN THE RAT-BRAIN", Life sciences, 58(18), 1996, pp. 1551-1559

Abstract

Hyperthyroidism is often associated with behavioral disorders, and thyroid hormones modify receptor sensitivity as well as the synthesis and/or turnover rate of many neurotransmitters. We evaluated the influence in adult rats of triiodothyronine (T-3), administred s.c. (100 mu g/kg) acutely (once only) or chronically (once a day for 3 or 7 consecutive days), on brain serotonin concentration and on the density and affinity of two brain serotonin (5-HT) receptor subtypes mainly involvedin behavioral effects. After both acute and chronic T-3 treatment, serotonin levels increased in the cerebral cortex but not in the hippocampus. The density and affinity of 5-HT1A receptors (using [H-3]-8-OH-DPAT as ligand) were not affected, while there was a significant decrease in the number of 5-HT2 receptors in the cerebral cortex (using [H-3]ketanserin as ligand). This observation might indicate that thyroid hormones enhance 5-HT concentration in certain brain areas, thus causing a down-regulation of 5-HT2 receptors. The serotonergic system could be involved in the complex brain-neurotransmitter imbalance underlyinghyperthyroidism-linked behavioral changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:44:44