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Titolo:
CHARACTERIZATION OF REPRODUCTIVE HORMONAL DYNAMICS IN THE PERIMENOPAUSE
Autore:
SANTORO N; BROWN JR; ADEL T; SKURNICK JH;
Indirizzi:
UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT REPROD BIOL,185 S ORANGE AVE,MSB E-506 NEWARK NJ 07103 UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT OBSTET & GYNECOL NEWARK NJ 07103 UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT BIOSTAT & EPIDEMIOL NEWARK NJ 07103
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 4, volume: 81, anno: 1996,
pagine: 1495 - 1501
SICI:
0021-972X(1996)81:4<1495:CORHDI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-OVARIAN FUNCTION; MENOPAUSAL TRANSITION; WOMEN; GONADOTROPIN; AGE; ESTRADIOL; CYCLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
N. Santoro et al., "CHARACTERIZATION OF REPRODUCTIVE HORMONAL DYNAMICS IN THE PERIMENOPAUSE", The Journal of clinical endocrinology and metabolism, 81(4), 1996, pp. 1495-1501

Abstract

Medical therapy for women in the perimenopausal period is controversial, in part due to varying degrees of ovarian hormone secretion characteristic of this time of life. To extend our understanding of the reproductive endocrine milieu of perimenopausal women, we studied 6 cycling women, aged 47 yr and older, for 6 months with daily collections of first morning voided urine. Five additional older reproductive aged (43-47 yr old) women were studied with daily urine and serum sampling for a single menstrual cycle; their urinary hormone data were combined with the former group for menstrual cycle comparisons. Urine was assayed for LH, FSH, estrone conjugates, and pregnanediol glucuronide and normalized for creatinine (Cr). Eleven midreproductive aged (19-38 yr old) normally cycling women, 5 women with well defined premature ovarianfailure, and 5 women aged 54 yr and older who were at least 1 yr postmenopausal were used for comparison. Perimenopausal women had shorter follicular phases (11 +/- 2 days us. 14 +/- 1 days; P = 0.031) and, hence, shorter menstrual cycles than midreproductive aged controls. FSH excretion in perimenopausal women was greater than that in younger women (range of means, 4-32 us. 3-7 IU/g Cr; P = 0.0005). LH secretion was overall greater than that in younger normal subjects (range of means, 1.4-6.8 us. 1.1-4.2 IU/g Cr; P < 0.026). Overall mean estrone conjugate excretion was greater in the perimenopausal women compared to thatin the younger women [76.9 ng/mg Cr (range, 13.1-135) us. 40.7 ng/mg Cr (range, 22.8-60.3); P = 0.023] and was similarly elevated in both follicular and luteal phases. Luteal phase pregnanediol excretion was diminished in the perimenopausal women compared to that in younger normal subjects (range for integrated pregnanediol, 1.0-8.4 vs. 1.6-12.7 mu g/mg Cr/luteal phase; P = 0.015). Compared to postmenopausal women, perimenopausal women had more overall estrone excretion (2.5-6.2 ng/mgCr in postmenopausal women; P = 0.02) and lower mean FSH (range of means for postmenopause, 24-85 IU/g Cr; P = 0.017) and LH (range for postmenopause, 4.3-14.8 IU/g Cr; P = 0.041). Compared to women with premature menopause, perimenopausal women again had lower FSH (range of means for premature menopause, 36-82 IU/g Cr; P = 0.0022), lower LH (range of means for premature menopause, 5.5-23.8 IU/g Cr; P = 0.0092), borderline higher mean estrone conjugates (range of means for premature menopause, 4-44 ng/mg Cr; P = 0.064), and far longer periods of ovarianactivity (one to two cycles in prematurely menopausal women us. threeto six cycles in perimenopausal women). We conclude that altered ovarian function in the perimenopause can be observed as early as age 43 yr and include hyperestrogenism, hypergonadotropism, and decreased luteal phase progesterone excretion. These hormonal alterations may well be responsible for the increased gynecological morbidity that characterizes this period of life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:21:28