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Titolo:
ALLELIC ASSOCIATION OF GENE MARKERS ON CHROMOSOMES 5Q AND 11Q WITH ATOPY AND BRONCHIAL HYPERRESPONSIVENESS
Autore:
DOULL IJM; LAWRENCE S; WATSON M; BEGISHVILI T; BEASLEY RW; LAMPE F; HOLGATE ST; MORTON NE;
Indirizzi:
UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,TREMONA RD,CTR BLOCK SOUTHAMPTON SO16 6YD HANTS ENGLAND WELLINGTON SCH MED WELLINGTON NEW ZEALAND
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 153, anno: 1996,
parte:, 1
pagine: 1280 - 1284
SICI:
1073-449X(1996)153:4<1280:AAOGMO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TH1; LINKAGE; ASTHMA; IL-4; IGE; RESPONSIVENESS; INTERLEUKIN-4; LOCALIZATION; NO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
I.J.M. Doull et al., "ALLELIC ASSOCIATION OF GENE MARKERS ON CHROMOSOMES 5Q AND 11Q WITH ATOPY AND BRONCHIAL HYPERRESPONSIVENESS", American journal of respiratory and critical care medicine, 153(4), 1996, pp. 1280-1284

Abstract

To investigate genetic factors in asthma and atopy, we sought allelicassociations for 12 markers near candidate loci for serum total, immunoglobulin E (IgE), and bronchial hyperresponsiveness (BHR) to inhaledhistamine in 131 families comprising 685 individuals, selected randomly without regard to atopy or asthma. Nonparametric linkage and association analyses were performed with the Nonparametric Analysis of Lineage and Association (NOPAR) program, and parametric analyses were performed with the Complex Inheritance with Diathesis and Severity (COMDS) program on an ordered polychotomy of ranked scores. On chromosome 11q,allele 168 at the D11S527 locus was significantly associated with BHR(p < 0.0003) but not with log IgE. At the D11S534 locus, allele 235 was significantly associated with log IgE (p = 0.007) but not with BHR. Both D11S527 and D11S534 were too distant from the gene encoding the high-affinity IgE receptor Fc,RIP to account for the association. At the interleukin-9 (IL-9) locus, the 118 allele showed significant association with serum total IgE (p < 0.003) but not with histamine BHR. Parametric tests are more conservative, perhaps because they demand consistency with mendelian inheritance and tight linkage. These findings provide support for the view that both chromosomes 5 and 11 may containgenes relevant to asthma and atopy, a possible candidate being the interleukin-4 (IL-4) gene cluster. Because these associations are extremes in a large number of tests, they require confirmation in other samples.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 14:06:32