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Titolo:
CONCENTRATIONS OF METHACHOLINE FOR BRONCHIAL RESPONSIVENESS ACCORDINGTO SYMPTOMS, SMOKING, AND IMMUNOGLOBULIN-E IN A POPULATION-BASED STUDY IN SPAIN
Autore:
SUNYER J; MUNOZ A; ANTO JM; MARTINEZMORATALLA J; ALMAR E; AREVALO M; MATEOS A; SANCHEZ A; VIZCAYA M; BURGOS F; CASTELLSAGUE J; GALOBARDES MB; ROCA J; SORIANO JB; MUNIOZGUREN N; ERRAZOLA M; CAPELASTEGUI A; RAMOS J; MALDONADO JA; SANCHEZ JL; PEREIRA A; GRAVALOS J; QUIROS R; AZOFRA J; PALENCIANO L; PAYO F; REGO G; VEGA A;
Indirizzi:
JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,624 N BROADWAY,SUITE 797 BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL BALTIMORE MD 21205 INST MUNICIPAL INVEST MED,DEPT EPIDEMIOL & PUBL HLTH E-08003 BARCELONA SPAIN
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 153, anno: 1996,
parte:, 1
pagine: 1273 - 1279
SICI:
1073-449X(1996)153:4<1273:COMFBR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RESPONSE CURVES; AIRWAY HYPERRESPONSIVENESS; HISTAMINE; ASTHMA; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Sunyer et al., "CONCENTRATIONS OF METHACHOLINE FOR BRONCHIAL RESPONSIVENESS ACCORDINGTO SYMPTOMS, SMOKING, AND IMMUNOGLOBULIN-E IN A POPULATION-BASED STUDY IN SPAIN", American journal of respiratory and critical care medicine, 153(4), 1996, pp. 1273-1279

Abstract

To assess the simultaneous effects of symptoms related to asthma, smoking, and Immunoglobulin E (IgE) on the concentrations of methacholineat which different individuals fall below 80% the FEV(1) values obtained with saline, we used parametric survival methods that fit the dose-response nature of bronchial responsiveness (BR). A general population-based sample of 1,615 adults (aged 20 to 44 yr) from five cities in Spain participating in the European Community Respiratory Health Survey was studied. The total number of subjects whose FEV(1) values dropped below 80% was 237 (14.7%). We found that individuals with symptoms related to asthma, whether they were smokers or nonsmokers, responded at lower concentrations of methacholine than individuals without symptoms. The greatest decrease in the concentrations of methacholine at which different percentages of individuals responded was due to symptoms among the nonsmokers (relative percentiles ranging from 0.53 to 0.76, and a 90% confidence band not containing a value one). Among individuals without symptoms, smokers responded at moderately but significantlylower concentrations than nonsmokers, whereas an apparent protective effect of smoking was seen in symptomatic individuals, owing in part to a self-selection bias. The higher the concentration of IgE, the lower were the concentrations of methacholine needed to obtain a given level of BR. Moreover, the magnitude of the decrease in methacholine concentrations leading to a response was constant over all percentages of individuals responding. The analytical methods used in the study permit the incorporation of complexities in the relationships between BR and symptoms, smoking, and Ig E, and are generally applicable to situations in which a dose-response relationship occurs.

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Documento generato il 28/03/20 alle ore 22:37:20