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Titolo:
ANTIHYPERTENSIVE AND RENAL EFFECTS OF ACUTE AND CHRONIC THERAPY WITH A DIHYDROPYRIDINE CA-ANTAGONIST IN PATIENTS WITH DIFFERENT SALT SENSITIVITY
Autore:
GALLETTI F; STRAZZULLO P; BARBA G; FERRARA I; IACONE R; STINGA F;
Indirizzi:
UNIV NAPLES FEDERICO II,DIPARTIMENTO MED CLIN & SPERIMENTALE,FAC MED & CHIRURG,SCH MED I-80131 NAPLES ITALY
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 27, anno: 1996,
pagine: 578 - 582
SICI:
0160-2446(1996)27:4<578:AAREOA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; URINARY CALCIUM EXCRETION; BLOOD-PRESSURE; SODIUM-INTAKE; DIETARY-SODIUM; NIFEDIPINE; RESPONSES; BLOCKADE; METABOLISM; AGE;
Keywords:
NITRENDIPINE; SALT SENSITIVITY; URINARY NA AND CA EXCRETION; SODIUM; CALCIUM; CA ANTAGONIST; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
F. Galletti et al., "ANTIHYPERTENSIVE AND RENAL EFFECTS OF ACUTE AND CHRONIC THERAPY WITH A DIHYDROPYRIDINE CA-ANTAGONIST IN PATIENTS WITH DIFFERENT SALT SENSITIVITY", Journal of cardiovascular pharmacology, 27(4), 1996, pp. 578-582

Abstract

We evaluated the effect of the dihydropyridine Ca-channel blocker nitrendipine on blood pressure (BP) and electrolyte urinary excretion after acute and chronic therapy in 33 patients with different NaCl sensitivity as assessed by a modification of the test of Grim and colleagues. Acute nitrendipine administration significantly reduced BP in the group as a whole, although the hypotensive effect was greater in patients with greater NaCl sensitivity; this difference was still evident after 1 month of chronic therapy. Furthermore, urinary sodium and calciumexcretion significantly increased in the 3 h after nitrendipine administration during both acute and chronic therapy: these effects on electrolyte excretion were independent of the NaCl sensitivity of the subject.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:13:30