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Titolo:
EFFECT OF BERAPROST, A STABLE PROSTACYCLIN ANALOG, ON RED-BLOOD-CELL DEFORMABILITY IMPAIRMENT IN THE PRESENCE OF HYPERCHOLESTEROLEMIA IN RABBITS
Autore:
HAYASHI J; ISHIDA N; SATO H; HATA Y; SAITO T;
Indirizzi:
KYORIN UNIV,SCH MED,DEPT MED & GERONTOL,SHINKAWA 6-20-2 MITAKA TOKYO 181 JAPAN KYORIN UNIV,SCH MED,DEPT BIOL MITAKA TOKYO 181 JAPAN
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 27, anno: 1996,
pagine: 527 - 531
SICI:
0160-2446(1996)27:4<527:EOBASP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-DISEASE; ERYTHROCYTES; RHEOLOGY; PROSTAGLANDIN-I2; CATECHOLAMINES; FILTERABILITY; FILTRATION; PLATELETS; INVITRO; SODIUM;
Keywords:
RED BLOOD CELL DEFORMABILITY; BERAPROST (A STABLE ANALOG OF PROSTACYCLIN); HYPERCHOLESTEROLEMIA; PRAVASTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Hayashi et al., "EFFECT OF BERAPROST, A STABLE PROSTACYCLIN ANALOG, ON RED-BLOOD-CELL DEFORMABILITY IMPAIRMENT IN THE PRESENCE OF HYPERCHOLESTEROLEMIA IN RABBITS", Journal of cardiovascular pharmacology, 27(4), 1996, pp. 527-531

Abstract

We evaluated the effects of orally administered beraprost, a stable prostacyclin analogue, on the rheological behavior of red blood cells (RBC) in the presence of hypercholesterolemia. Rabbits fed a cholesterol-rich diet were administered various doses of beraprost or pravastatin. We evaluated rheological behavior of RBC by assessing RBC deformability, using a positive-pressure filtration method. The maximum pressure generated by passing a suspension of RBC through a membrane filter was used as an index of RBC deformability. After animals were fed cholesterol for 16 weeks, the maximum pressure increased significantly from172 +/- 15 mm Hg at baseline to 261 +/- 18 mm Hg (p < 0.01, n = 24). The reduction in RBC deformability associated with hypercholesterolemia improved dose dependently during l-h incubation with various doses of beraprost. In ex vivo study, beraprost markedly restored RBC deformability 3 h after its oral administration to 218 +/- 17 mm Hg (n = 9) at a low dose and to 215 +/- 20 mm Hg (n = 9) at a high dose. The effect persisted for at least 2 h. Pravastatin failed to reduce the increased maximum pressure. Findings suggest that beraprost treatment may improve the microcirculation by restoring RBC deformability in the presence of hypercholesterolemia.

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Documento generato il 04/08/20 alle ore 12:01:02