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Titolo:
IN-SITU HYBRIDIZATION STUDY OF MYELIN PROTEIN MESSENGER-RNA IN RATS WITH AN EXPERIMENTAL DIABETIC NEUROPATHY
Autore:
CONTI AM; SCARPINI E; MALOSIO ML; DIGIULIO AM; BARON P; SCARLATO G; MANTEGAZZA P; GORIO A;
Indirizzi:
UNIV MILAN,DINO FERRARI CTR,INST NEUROL,VIA F SFORZA 35 I-20122 MILANITALY UNIV MILAN,DINO FERRARI CTR,INST NEUROL I-20122 MILAN ITALY UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL MILAN ITALY
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 207, anno: 1996,
pagine: 65 - 69
SICI:
0304-3940(1996)207:1<65:IHSOMP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXO-GLIAL DYSJUNCTION; PERIPHERAL MYELIN; NERVOUS-SYSTEM; PATHOGENESIS; TRANSPORT; LECTURE;
Keywords:
EXPERIMENTAL DIABETIC NEUROPATHY; MYELIN PROTEINS; ALLOXAN-INDUCED DIABETES; IN SITU HYBRIDIZATION; PERIPHERAL NERVE; PROTEIN ZERO (P-O); MYELIN BASIC PROTEIN (MBP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Conti et al., "IN-SITU HYBRIDIZATION STUDY OF MYELIN PROTEIN MESSENGER-RNA IN RATS WITH AN EXPERIMENTAL DIABETIC NEUROPATHY", Neuroscience letters, 207(1), 1996, pp. 65-69

Abstract

Distribution of protein zero (P-o) and myelin basic protein (MBP) mRNAs in the sciatic nerve from rats with alloxan-induced diabe- tes was analyzed at two different time points using in situ hybridization. Some animals of each diabetic group were treated with insulin. Densitometric quantitation of silver clusters revealed that 5 weeks after diabetes induction P-o mRNA only is significantly increased, while at 14 weeks both P-o and MBP mRNA contents are markedly higher than controls. Insulin treatment normalizes glycemia levels and slightly counteracts increased Po mRNA at both stages of diabetes. An increase in MBP mRNA is observed in chronic diabetic animals only, and is unaltered by the normoglycemic effect of insulin. The increased transcript levels of Po and MBP suggest that Schwann cells can modulate gene expression of myelin-specific proteins in response to diabetic-induced metabolic derangement. Such a change may represent a higher turnover of myelin proteins as an attempt by the Schwann cells to repair the diabetes-induced nerve damage. The observed pattern of transcript amount is only slightlyinfluenced by insulin treatment.

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Documento generato il 30/09/20 alle ore 07:20:13