Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BRAIN ALPHA(1)-ADRENOCEPTOR IN THE CARDIOVASCULAR-RESPONSES TO BHT-920 AND PHENYLEPHRINE
Autore:
RICCI D; TAIRA CA;
Indirizzi:
UNIV BUENOS AIRES,FAC FARM & BIOQUIM,CATEDRA FARMACOL,JUNIN 956 PISO 5TO RA-1113 BUENOS AIRES DF ARGENTINA
Titolo Testata:
General pharmacology
fascicolo: 2, volume: 27, anno: 1996,
pagine: 299 - 304
SICI:
0306-3623(1996)27:2<299:BAITCT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC-DENERVATED RATS; BLOOD-PRESSURE; HEART-RATE; CLONIDINE; RECEPTORS; RABBITS; REFLEX; DRUGS;
Keywords:
ALPHA(1)-ADRENOCEPTOR; BHT-920; PHENYLEPHRINE; PRAZOSIN; SINOAORTIC DENERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D. Ricci e C.A. Taira, "BRAIN ALPHA(1)-ADRENOCEPTOR IN THE CARDIOVASCULAR-RESPONSES TO BHT-920 AND PHENYLEPHRINE", General pharmacology, 27(2), 1996, pp. 299-304

Abstract

1. It is well known that alpha(1A)-adrenoceptors have binding sites for imidazolic and for phenylethylaminic drugs. A study was made relating alpha(1A)-adrenoceptor involvement in cardiovascular responses to intracerebroventricular (ICV) injection of BHT-920, an imidazoliclike drug, and phenylephrine, a phenylethylaminic drug, in conscious sham-operated and sinoaortically-denervated rats. 2. In sham-operated rats, cardiovascular responses to BHT-920 (30 mu g, ICV) were increase of blood pressure and bradycardia but in sinoaortically denervated rats, after the presser response, a decrease of blood pressure was also seen. The presser and bradycardic responses to agonist were greater in sinoaortically denervated rats than in sham operated rats. Phenylephrine (90mu g, ICV) showed a biphasic effect on blood pressure: an increase followed by a decrease, and bradycardia. The cardiovascular responses tophenylephrine in sinoaortic denervated rats were greater than in shamoperated rats. 3. In sinoaortically denervated and sham operated ratssubchronically treated with the al adrenoceptor antagonist prazosin (0.5 mg kg(-1), intraperitoneally twice daily, for 6 days), an increaseof cardiovascular responses to ICV administration of BHT-920 and phenylephrine was seen. 4. Baroreceptor deafferentation by sinoaortic denervation enhances the cardiovascular responses to BHT-920 and phenylephrine. The effects of BHT-920 could be mediated by brain alpha(1A)-adrenoceptors because this agonist has an imidazoliclike structure; phenylephrine could also be activating central ala adrenoceptors. The enhanced cardiovascular responses after prazosin treatment could also be dueto a supersensitivity of brain alpha(1A)-adrenoceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:39:36