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Titolo:
METABOLIC-FATE OF AN ORAL TRACER DOSE OF [C-13]DOCOSAHEXAENOIC ACID TRIGLYCERIDES IN THE RAT
Autore:
BROSSARD N; CROSET M; LECERF J; PACHIAUDI C; NORMAND S; CHIROUZE V; MACOVSCHI O; RIOU JP; TAYOT JL; LAGARDE M;
Indirizzi:
CHIM BIOL INSA,INSERM U352,BAT 406,20 AV A EINSTEIN F-69621 VILLEURBANNE FRANCE CHIM BIOL INSA,INSERM U352 F-69621 VILLEURBANNE FRANCE FAC MED ALEXIS CARREL,INSERM U197 F-69372 LYON FRANCE IMEDEX,ZONE IND TROQUES F-69630 CHAPONOST FRANCE
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 39, anno: 1996,
pagine: 846 - 854
SICI:
0363-6119(1996)39:4<846:MOAOTD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN METABOLISM; PLATELET PHOSPHOLIPIDS; DOCOSAHEXAENOIC ACIDS; ETHYL-ESTERS; PLASMA; N-3; BRAIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLCHOLINE; ABSORPTION;
Keywords:
DOCOSAHEXAENOIC ACID; STABLE ISOTOPES; LIPOPROTEINS; BLOOD CELLS; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
N. Brossard et al., "METABOLIC-FATE OF AN ORAL TRACER DOSE OF [C-13]DOCOSAHEXAENOIC ACID TRIGLYCERIDES IN THE RAT", American journal of physiology. Regulatory, integrative and comparative physiology, 39(4), 1996, pp. 846-854

Abstract

The appearance of C-13 in rat lipoprotein, blood cells, and brain Lipids was followed as a function of time after the ingestion of triglycerides (TG) containing [C-13]22:6n-3. The time course of C-13 abundancein 22:6n-3 of various lipid pools, measured by gas chromatography combustion-isotope mass spectrometry, established precursor-product relationships within lipids. The [C-13]22:6n-3 was rapidly incorporated into very low density lipoprotein-chylomicron-TG and unesterified fatty acids bound to albumin, with a concomitant maximal appearance at 3 h and further decline. Lysophosphatidylcholines (lysoPC) bound to albumin were also enriched in [C-13]22:6n-3, and their labeling appeared to bemainly due to hepatic secretion at the earliest time points. From 12 h postingestion, the synthesis of [C-13]22:6n-3-lysoPC was twice as high as that of unesterified [C-13] 22:6n-3, making lysoPC a potential source of 22:6n-3 supply for tissues. The labeling of platelets, red blood cells, and brain phospholipids presented different kinetics, presumably involving the two lipid forms of [C-13]22:6n-3 bound to albumin,to different extents. We conclude that [C-13]22:6n-3 esterified in TGis rapidly redistributed within blood lipoproteins and the albumin fraction and that its incorporation in lipid species bound to albumin influences its uptake by target tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:47:39