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Titolo:
A COMMON TCR BETA-CHAIN EXPRESSED BY CD8(-MUCOSA T-CELLS IN ULCERATIVE-COLITIS() INTESTINAL)
Autore:
CHOTT A; PROBERT CS; GROSS GG; BLUMBERG RS; BALK SP;
Indirizzi:
BETH ISRAEL HOSP,DIV HEMATOL ONCOL,330 BROOKLINE AVE BOSTON MA 02215 BETH ISRAEL HOSP,DIV HEMATOL ONCOL BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 02215 BRIGHAM & WOMENS HOSP,DIV GASTROENTEROL BOSTON MA 02115 UNIV VIENNA,DEPT CLIN PATHOL VIENNA AUSTRIA
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 156, anno: 1996,
pagine: 3024 - 3035
SICI:
0022-1767(1996)156:8<3024:ACTBEB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; RECEPTOR-V-BETA; INTRAEPITHELIAL LYMPHOCYTES; LAMINA PROPRIA; PHENOTYPIC ANALYSIS; ANTIGEN RECEPTOR; PERIPHERAL-BLOOD; ALPHA-CHAIN; EPITHELIUM; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Chott et al., "A COMMON TCR BETA-CHAIN EXPRESSED BY CD8(-MUCOSA T-CELLS IN ULCERATIVE-COLITIS() INTESTINAL)", The Journal of immunology, 156(8), 1996, pp. 3024-3035

Abstract

The human intestine contains two populations of anatomically distinctT cells, intraepithelial lymphocytes and lamina propria lymphocytes (LPLs), both of which preferentially use the TCR-alpha beta. Recent studies of TCR alpha- and beta-chain usage by intestinal intraepithelial lymphocytes, which are predominantly CD8(+) T cells, have demonstratedthat these cells are oligoclonal in normal intestine. This report examined the TCR beta-chains expressed by purified CD4(+) and CD8(+) T cells from normal colonic lamina propria and from the intestinal mucosa of patients with active ulcerative colitis (UC). The selective expansion of CD8(+) T cell clones, and to a lesser extent CD4(+) T cell clones, was observed among both normal LPLs and mucosal T cells in UC. These expanded LPL clones from normal donors were all distinct, but the mucosal T cells isolated from five of nine patients with UC contained CD8(+) T cells expressing related V beta 3-J beta 1.6 TCRs. These observations provide evidence for an Ag-specific mucosal T cell response in UC. Further studies will be required to identify this Ag and address whether the T cell response to it plays a primary role in initiating the disease or is secondary to the inflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 18:42:41