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Titolo:
RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINE, VITAMIN STATUS AND EXTRACRANIAL CAROTID-ARTERY STENOSIS IN THE FRAMINGHAM-STUDY POPULATION
Autore:
SELHUB J; JACQUES PF; BOSTOM AG; DAGOSTINO RB; WILSON PWF; BELANGER AJ; OLEARY DH; WOLF PA; RUSH D; SCHAEFER EJ; ROSENBERG IH;
Indirizzi:
TUFTS UNIV,USDA,JEAN MAYER HUMAN NUTR RES CTR AGING,711 WASHINGTON STBOSTON MA 02111 NHLBI,FRAMINGHAM HEART DIS EPIDEMIOL STUDY FRAMINGHAM MA 01701 BOSTON UNIV,DEPT MATH,STAT & CONSULTING UNIT BOSTON MA 02111 GEISINGER MED CTR,DEPT RADIOL DANVILLE PA 17821 BOSTON UNIV,SCH MED,DEPT NEUROL BOSTON MA 02111 UNIV BOSTON HOSP,EVANS MEM DEPT CLIN RES,PREVENT MED & EPIDEMIOL SECTBOSTON MA 02111 UNIV BOSTON HOSP,DEPT MED BOSTON MA 02111
Titolo Testata:
The Journal of nutrition
fascicolo: 4, volume: 126, anno: 1996, supplemento:, S
pagine: 1258 - 1265
SICI:
0022-3166(1996)126:4<1258:RBPHVS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-DISEASE; RISK FACTOR; FOLIC-ACID; HOMOCYST(E)INE; HYPERHOMOCYSTEINEMIA; ATHEROSCLEROSIS; QUESTIONNAIRE; METABOLISM; THERAPY; FOLATE;
Keywords:
HOMOCYSTEINE; FOLIC ACID; PYRIDOXAL PHOSPHATE; VITAMIN-B-6; VITAMIN-B-12; ARTERIOSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Selhub et al., "RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINE, VITAMIN STATUS AND EXTRACRANIAL CAROTID-ARTERY STENOSIS IN THE FRAMINGHAM-STUDY POPULATION", The Journal of nutrition, 126(4), 1996, pp. 1258-1265

Abstract

Recent studies demonstrated associations between occlusive vascular disease and hyperhomocysteinemia of both genetic and nutritional origin. In the present study we analyzed plasma samples from the 20th biannual examination of the Framingham Heart Study cohort to determine distribution of plasma homocysteine concentrations with emphasis on relationships to B vitamins and prevalence of carotid artery stenosis. Results showed that homocysteine exhibited strong inverse association with plasma folate and weaker associations with plasma vitamin B-12 and pyridoxal-5'-phosphate (PLP). Homocysteine was also inversely associated with intakes of folate and vitamin B-6, but not vitamin B-12. prevalence of high homocysteine (>14 mu mol/l) was 29.3% in this cohort, and inadequate plasma concentrations of one or more B vitamins appear to contribute to 67% of the cases of high homocysteine, Prevalence of stenosis greater than or equal to 25% was 43% in men and 34% in women with an odds ratio of 2.0 for individuals in the highest homocysteine quartile (greater than or equal to 14.4 mu mol/l) compared with those in thelowest quartile (less than or equal to 9.1 mu mol/l), after adjustment for sex, age, high density lipoprotein cholesterol, systolic blood pressure and cigarette smoking (P-trend < 0.001). plasma concentrationsof folate and pyridoxal-5'-phosphate and folate intake were inverselyassociated with extracranial carotid stenosis after adjustment for age, sex and other risk factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:49:01