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Titolo:
EFFECTS OF VITAMIN-K ON BONE MASS AND BONE METABOLISM
Autore:
VERMEER C; GIJSBERS BLMG; CRACIUN AM; GROENENVANDOOREN MMCL; KNAPEN MHJ;
Indirizzi:
UNIV LIMBURG,DEPT BIOCHEM,POB 616 6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT 6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
The Journal of nutrition
fascicolo: 4, volume: 126, anno: 1996, supplemento:, S
pagine: 1187 - 1191
SICI:
0022-3166(1996)126:4<1187:EOVOBM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CALCIUM EXCRETION; ORAL ANTICOAGULANTS; DEPENDENT PROTEINS; CIRCULATING LEVELS; MINERAL CONTENT; ELDERLY WOMEN; HIP FRACTURE; GLA PROTEIN; OSTEOCALCIN; OSTEOPOROSIS;
Keywords:
VITAMIN-K; BONE MASS; BONE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C. Vermeer et al., "EFFECTS OF VITAMIN-K ON BONE MASS AND BONE METABOLISM", The Journal of nutrition, 126(4), 1996, pp. 1187-1191

Abstract

Vitamin a is involved in blood coagulation and in bone metabolism viathe carboxylation of glutamate residues in (hepatic) blood coagulation factors and (osteoblastic) bone proteins. The bioavailability of nutritional vitamin K depends on the type of food, the dietary fat content, the length of the aliphatic side chain in the K-vitamer and probably also the genetically determined polymorphism of apolipoprotein E. Although undercarboxylation of blood coagulation factors is very rare, undercarboxylated osteocalcin (bone Gla-protein) is frequently found inpostmenopausal women. Supplementation of these women with extra vitamin K causes the markers for bone formation to increase. In parallel, adecrease of the markers for bone resorption is frequently seen. Insufficient data are available to conclude that the regular administrationof vitamin K concentrates will reduce the loss of bone mass in white women at risk for developing postmenopausal osteoporosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:47:21