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Titolo:
CALCIUM AGONISTS AND ANTAGONISTS OF THE DIHYDROPYRIDINE TYPE - EFFECTON NICOTINE-INDUCED ANTINOCICEPTION AND HYPOMOTILITY
Autore:
DAMAJ MI; MARTIN BR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298
Titolo Testata:
Drug and alcohol dependence
fascicolo: 1, volume: 32, anno: 1993,
pagine: 73 - 79
SICI:
0376-8716(1993)32:1<73:CAAAOT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTORS; CATECHOLAMINE SECRETION; CHROMAFFIN CELLS; ADRENAL-MEDULLA; MORPHINE; RELEASE; SYNAPTOSOMES; STIMULATION; NIFEDIPINE; ANALGESIA;
Keywords:
CALCIUM ANTAGONISTS; BAYK-8644; NICOTINE; ANTINOCICEPTION; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Damaj e B.R. Martin, "CALCIUM AGONISTS AND ANTAGONISTS OF THE DIHYDROPYRIDINE TYPE - EFFECTON NICOTINE-INDUCED ANTINOCICEPTION AND HYPOMOTILITY", Drug and alcohol dependence, 32(1), 1993, pp. 73-79

Abstract

The influence of a calcium agonist (BAYK 8644) and several calcium channel blockers on nicotine-induced antinociception was investigated inmice. The effect of nicotine was sharply increased by BAYK 8644. Thispotentitation by BAYK 8644 was blocked by pretreating the animals with nifedipine at 2 and 10 mg/kg. The calcium channel antagonigts, nifedipine and nimodipine at doses that had no effect on tail-flick time, reduced significantly the antinociception induced by nicotine (1.5 mg/kg, s.c.). However, the effect of verapamil on nicotine was not significant. These results indicate that DHP calcium channels (type L-channel) play a role in some of the pharmacological effects of nicotine, particularly, locomotor activity and antinociception.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 03:51:31