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Titolo:
EXPRESSION AND INSULIN-REGULATED DISTRIBUTION OF CAVEOLIN IN SKELETAL-MUSCLE - CAVEOLIN DOES NOT COLOCALIZE WITH GLUT4 IN INTRACELLULAR MEMBRANES
Autore:
MUNOZ P; MORA S; SEVILLA L; KALIMAN P; TOMAS E; GUMA A; TESTAR X; PALACIN M; ZORZANO A;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & BIOL MOLEC,AVDA DIAGONAL 645 E-08028 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & BIOL MOLEC E-08028 BARCELONA SPAIN
Titolo Testata:
The Journal of biological chemistry
fascicolo: 14, volume: 271, anno: 1996,
pagine: 8133 - 8139
SICI:
0021-9258(1996)271:14<8133:EAIDOC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-TRANSPORTER GLUT4; RAT ADIPOCYTES; SUBCELLULAR-DISTRIBUTION; PROTEINS; VESICLES; COMPONENT; BINDING; CELLS; DIFFERENTIATION; TRANSLOCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
P. Munoz et al., "EXPRESSION AND INSULIN-REGULATED DISTRIBUTION OF CAVEOLIN IN SKELETAL-MUSCLE - CAVEOLIN DOES NOT COLOCALIZE WITH GLUT4 IN INTRACELLULAR MEMBRANES", The Journal of biological chemistry, 271(14), 1996, pp. 8133-8139

Abstract

Caveolin is believed to play an important role in sorting processes, vesicular trafficking, transmembrane signaling, and molecular transport across membranes, In this study we have evaluated the expression anddistribution of caveolin in skeletal muscle and its interaction with GLUT4 glucose carriers, Caveolin was expressed to substantial levels in muscle and its expression was regulated in muscle; aging and high fat diet enhanced caveolin expression in skeletal muscle and inversely, myogenesis down-regulated caveolin in L6E9 cells. Under fasting conditions, most of caveolin was found in intracellular membranes and the caveolin present in the cell surface was found in both sarcolemma and T-tubules, Insulin administration led to a redistribution of caveolin from intracellular high density membrane fractions to intracellular lighter density fractions and to the cell surface; this pattern of insulin-induced redistribution was different to what was shown by GLUT4. These results suggests that caveolin is a component of an insulin-regulated machinery of vesicular transport in muscle. Quantitative immunoisolation of GLUT4 vesicles obtained from different intracellular GLUT4 populations revealed the absence of caveolin which substantiates the lackof colocalization of intracellular GLUT4 and caveolin, This indicatesthat caveolin is not involved in intracellular GLUT4 trafficking in skeletal muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:29:09