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Titolo:
TYROSINE ADMINISTRATION PREVENTS HYPOXIA-INDUCED DECREMENTS IN LEARNING AND MEMORY
Autore:
SHUKITTHALE B; STILLMAN MJ; LIEBERMAN HR;
Indirizzi:
USA,ENVIRONM MED RES INST,MIL NUTR DIV NATICK MA 01760 GEOCENTERS INC NEWTON MA 02159 USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV NATICK MA 01760
Titolo Testata:
Physiology & behavior
fascicolo: 4-5, volume: 59, anno: 1996,
pagine: 867 - 871
SICI:
0031-9384(1996)59:4-5<867:TAPHDI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS;
Keywords:
HYPOBARIC HYPOXIA; ALTITUDE EXPOSURE; PRECURSOR; REFERENCE MEMORY; WORKING MEMORY; MORRIS WATER MAZE; SPATIAL MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B. Shukitthale et al., "TYROSINE ADMINISTRATION PREVENTS HYPOXIA-INDUCED DECREMENTS IN LEARNING AND MEMORY", Physiology & behavior, 59(4-5), 1996, pp. 867-871

Abstract

Exposure to hypobaric hypoxia rapidly produces decrements in learningand memory. Tyrosine, a neurotransmitter precursor, has beneficial behavioral effects when administered to animals and humans exposed to various acute stressors. To determine whether tyrosine would protect rats from the adverse effects of hypobaric hypoxia on spatial reference and working memory, it was administered to 27 male Fischer 344 rats tested in the Morris water maze, Rats were tested starting at 2 and 6 h of an 8 h exposure to a simulated altitude of 5950 m (19,500 ft) or sealevel. Tyrosine or placebo was administered 1/2 h prior to each testing session (400 mg/kg, IP). Altitude exposure significantly increased working memory escape latency; treatment with tyrosine reversed this decrement. There was no effect of altitude or tyrosine on reference memory. There were also no treatment-related differences in performance when animals were tested the next day at sea level, The beneficial effects of tyrosine on working memory performance may be due to a direct effect of tyrosine on memory, alleviation of a hypoxia-induced retardation of learning, or to other central or peripheral effects of this dietary catecholamine precursor.

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Documento generato il 02/04/20 alle ore 12:53:56