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Titolo:
INCREASED PLASMA IGF-1 LEVELS BUT LACK OF CHANGES IN ADIPOCYTE GLUCOSE-TRANSPORT IN WEANLING RATS WITH DORSOMEDIAL HYPOTHALAMIC NUCLEUS LESIONS 1 YEAR AFTER LESION PRODUCTION
Autore:
BERNARDIS LL; BENEDICT MR; DEZIEL MR; DAVIS FB; DAVIS PJ;
Indirizzi:
DEPT VET AFFAIRS MED CTR,NEUROVISCERAL LAB,3495 BAILEY AVE BUFFALO NY14215 SUNY BUFFALO,SCH MED & BIOMED SCI,FAC HLTH RELATED PROFESS,FAC MED,NUTR PROGRAM,DEPT ORTOPAED BUFFALO NY 14215 SUNY HLTH SCI CTR,DEPT PEDIAT,DIV ENDOCRINOL SYRACUSE NY 13219 ALBANY MED COLL,DEPT PHYSIOL & CELL BIOL ALBANY NY 12208 ALBANY MED COLL,DEPT MED,DIV MOL & CELLULAR MED ALBANY NY 12208
Titolo Testata:
Physiology & behavior
fascicolo: 4-5, volume: 59, anno: 1996,
pagine: 689 - 697
SICI:
0031-9384(1996)59:4-5<689:IPILBL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-RETARDED RATS; BINDING PROTEINS; INSULIN; HORMONE; AGE; SOMATOMEDIN; SECRETION; SERUM; RELEASE; OLD;
Keywords:
DORSOMEDIAL HYPOTHALAMIC NUCLEUS; AGING; FOOD INTAKE; BODY COMPOSITION; GLUCOSE TRANSPORT; INSULIN-LIKE GROWTH FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
L.L. Bernardis et al., "INCREASED PLASMA IGF-1 LEVELS BUT LACK OF CHANGES IN ADIPOCYTE GLUCOSE-TRANSPORT IN WEANLING RATS WITH DORSOMEDIAL HYPOTHALAMIC NUCLEUS LESIONS 1 YEAR AFTER LESION PRODUCTION", Physiology & behavior, 59(4-5), 1996, pp. 689-697

Abstract

Experimental destruction of the dorsomedial hypothalamic nuclei (DMN)in weanling rats exerts an antiaging effect by preventing microalbuminuria and kidney lesions both 1 month and 1 year after lesion production. In the present study we report further on antiaging effects of DMNlesions (DMNL) by measuring glucose transport into adipocytes and plasma levels of insulin-like growth factors 1 and 2 (IGF-I, ICE-II). Male and female weanling Sprague-Dawley rats received bilateral electrolytic lesions in the DMN; sham-operated animals served as controls (SCON). The rats were maintained for 1 year and food intake was measured 3 weeks after surgery and 3 weeks prior to sacrifice. As expected, DMNL resulted in profound reductions of body weight and food intake, with male DMNL rats showing higher body weights and body weight gains than their female counterparts. The same was true of the respective SCON. Inmale DMNL rats, carcass fat in absolute terms was significantly reduced vs, SCON, but it was comparable among all groups when expressed in percent. Lean body mass (LBM), although significantly reduced in absolute terms in DMNL rats vs. SCON, was, however, significantly higher inmale DMNL vs. SCON when expressed in percent, but not in females. LBMlaid down per food energy taken in was higher in DMNL rats of both sexes than in their respective SCON. Efficiency of food utilization was normal in male DMNL vs. male SCON but was higher in female DMNL vs. SCON. Both male and female DMNL rats had significantly higher plasma IGF-I concentrations than their respective SCON, and male DMNL rats had higher values than female DMNL rats. Plasma concentrations of IGF-II were significantly higher in DMNL vs. SCON, but only in females. Under both basal and insulin-stimulated conditions, DMNL rats had normal 3-0-methylglucose flux in adipocytes from epididymal fat pads vs. SCON. However, DMNL and SCON responded similarly to the stimulating effect of insulin. Although one-year-old rats may not be considered ''aged'', wedo consider the observed lack of a drop in plasma IGF-1 levels that occurs with aging as an ''anti-aging'' effect of DMN lesions.

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Documento generato il 29/09/20 alle ore 20:40:40