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Titolo:
COCAINE DOWN-REGULATES BETA-ADRENERGIC RECEPTORS IN PREGNANT SHEEP MYOMETRIUM
Autore:
WANG FL; GAUVIN JM; DOMBROWSKI MP; SMITH YR; CHRISTOPHER KA; HURD WW;
Indirizzi:
550 N UNIV BLVD,ROOM 2440 INDIANAPOLIS IN 46202 UNIV MICHIGAN,MED CTR,DEPT OBSTET & GYNECOL ANN ARBOR MI 48109 WAYNE STATE UNIV,DEPT OBSTET & GYNECOL DETROIT MI 00000
Titolo Testata:
Reproductive toxicology
fascicolo: 2, volume: 10, anno: 1996,
pagine: 119 - 123
SICI:
0890-6238(1996)10:2<119:CDBRIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING;
Keywords:
COCAINE; MYOMETRIUM; UTERUS; BETA-ADRENERGIC RECEPTORS; PREMATURE LABOR; SHEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
F.L. Wang et al., "COCAINE DOWN-REGULATES BETA-ADRENERGIC RECEPTORS IN PREGNANT SHEEP MYOMETRIUM", Reproductive toxicology, 10(2), 1996, pp. 119-123

Abstract

Cocaine abuse is associated with premature labor, Although cocaine isknown to competitively inhibit beta-adrenergic receptor binding, cocaine's effect on receptor downregulation is uncertain, This study was designed to determine the in vitro effect of cocaine on downregulation of beta-adrenergic receptors in pregnant myometrium. Pregnant sheep myometrium was incubated with either cocaine, isoproterenol, or a cocaine metabolite, benzoylecgonine. Membrane fractions were assayed for beta-adrenergic receptors using (I-125)-cyanopindolol and the beta(2)-adrenergic antagonist ICI 118,551. We found that cocaine (10(-6) to 10(-4) mol/L), but not benzoylecgonine, downregulated both beta(1)- and beta(2)-adrenergic receptors, but did not further augment receptor downregulation by isoproterenol. The 46% decrease in beta-adrenergic receptors seen after exposure to cocaine was similar to the 53% decrease seenafter isoproterenol, We hypothesize downregulation of beta-adrenergicreceptors by cocaine may play a role in the association of cocaine abuse with premature labor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:43:57