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Titolo:
CHROMATID-TYPE ABERRATIONS INDUCED BY ALUI IN CHINESE-HAMSTER OVARY CELLS
Autore:
OBE G; JOHANNES C; WERTHMANN I; FOLLE GA;
Indirizzi:
UNIV GH ESSEN,DEPT GENET,UNIVERSITATSSTR 5 W-4300 ESSEN 1 GERMANY INST INVEST BIOL CLEMENTE ESTABLE,DIV HUMAN CYTOGENET & QUANTITAT MICROSCOPY MONTEVIDEO 11600 URUGUAY
Titolo Testata:
MUTATION RESEARCH
fascicolo: 3-4, volume: 299, anno: 1993,
pagine: 305 - 311
SICI:
0027-5107(1993)299:3-4<305:CAIBAI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRAND BREAKS; INDUCED CHROMOSOME-ABERRATIONS; RESTRICTION ENDONUCLEASES; CHO-CELLS; NEUROSPORA ENDONUCLEASE; INSITU HYBRIDIZATION; PVU-II; BAM-HI; X-RAYS; DNA;
Keywords:
ALUI; CHROMATID-TYPE ABERRATION INDUCTION; CHO CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G. Obe et al., "CHROMATID-TYPE ABERRATIONS INDUCED BY ALUI IN CHINESE-HAMSTER OVARY CELLS", MUTATION RESEARCH, 299(3-4), 1993, pp. 305-311

Abstract

Treatment of CHO cells with AluI in the S-phase leads to chromatid-type aberrations whose frequencies are linearly correlated with dose. Treatment in the S-phase leads to fewer aberrations than treatment in the G1-phase, which is comparable to chromosomal aberration induction following X-irradiation in the G1- and S-phases. Treatment in the G1-phase leads to few chromatid-type interchanges, some of these may originate from DNA single-strand gaps induced by AluI in canonical structuresof DNA and in DNA - RNA hybrids.

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Documento generato il 25/11/20 alle ore 15:52:48