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Titolo:
PROBLEM OF DIAGNOSIS IN POSTMORTEM BRAIN STUDIES OF SCHIZOPHRENIA
Autore:
HILL C; KEKS N; ROBERTS S; OPESKIN K; DEAN B; MACKINNON A; COPOLOV D;
Indirizzi:
MENTAL HLTH RES INST VICTORIA,NATL HLTH & MED RES COUNCIL NETWORK BRAIN RES MEN,LOCKED BAG 11 PARKVILLE VIC 3052 AUSTRALIA MENTAL HLTH RES INST VICTORIA,NATL HLTH & MED RES COUNCIL NETWORK BRAIN RES MEN PARKVILLE VIC 3052 AUSTRALIA MONASH UNIV,DEPT MED PSYCHOL MELBOURNE VIC 3004 AUSTRALIA VISTORIAN INST FORENS PATHOL MELBOURNE VIC AUSTRALIA
Titolo Testata:
The American journal of psychiatry
fascicolo: 4, volume: 153, anno: 1996,
pagine: 533 - 537
SICI:
0002-953X(1996)153:4<533:PODIPB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SAMPLING BIASES; DSM-III; SYSTEMS; CRITERIA; GENDER; DEFINITIONS; CONCORDANCE; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C. Hill et al., "PROBLEM OF DIAGNOSIS IN POSTMORTEM BRAIN STUDIES OF SCHIZOPHRENIA", The American journal of psychiatry, 153(4), 1996, pp. 533-537

Abstract

Objective: The purpose of this study was to determine 1) the reliability of diagnoses of schizophrenia at coronal autopsy and 2) the degreeto which the use of different diagnostic instruments for schizophrenia would affect postmortem brain research. Method: Eighty-three subjects, recorded at coronal autopsy as having had schizophrenia, were referred for neurochemistry studies. The diagnoses reported to the state coroner's office were reevaluated by a review of psychiatric case histories by clinicians using semistructured assessment and diagnostic criteria. Results: The application of DSM-III-R, Research Diagnostic Criteria (RDC), ICD-10, Schneiderian, and Feighner criteria to the diagnosisof the 83 subjects revealed that 63.9%, 48.2%, 48.2%, 43.4%, and 42.2%, respectively, met the criteria for schizophrenia. Highest concordance was between the RDC and ICD-10 systems, while lowest concordance was between the RDC and Schneider systems. Conclusions: These data suggest that unless carefully reviewed, diagnosis may be a major confounding factor in postmortem studies of brain tissue from subjects with schizophrenia.

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Documento generato il 28/11/20 alle ore 04:40:37