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Titolo:
ARRESTING THE MITOTIC OSCILLATOR AND THE CONTROL OF CELL-PROLIFERATION - INSIGHTS FROM A CASCADE MODEL FOR CDC2 KINASE ACTIVATION
Autore:
GOLDBETER A; GUILMOT JM;
Indirizzi:
FREE UNIV BRUSSELS,FAC SCI,CAMPUS PLAINE,CP 231 B-1050 BRUSSELS BELGIUM
Titolo Testata:
Experientia
fascicolo: 3, volume: 52, anno: 1996,
pagine: 212 - 216
SICI:
0014-4754(1996)52:3<212:ATMOAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEE1 TYROSINE KINASE; CYCLIN; PROTEIN; MITOSIS; PHASE; PHOSPHORYLATION; DEGRADATION; EXTRACTS; COMPLEX; P34CDC2;
Keywords:
CELL CYCLE; G(1)/S AND G(2)/M TRANSITIONS; METAPHASE ARREST; CELL PROLIFERATION; BIOCHEMICAL OSCILLATIONS; PHOSPHORYLATION-DEPHOSPHORYLATION CASCADE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Goldbeter e J.M. Guilmot, "ARRESTING THE MITOTIC OSCILLATOR AND THE CONTROL OF CELL-PROLIFERATION - INSIGHTS FROM A CASCADE MODEL FOR CDC2 KINASE ACTIVATION", Experientia, 52(3), 1996, pp. 212-216

Abstract

We consider a minimal cascade model previously proposed(11) for the mitotic oscillator driving the embryonic cell division cycle. The modelis based on a bicyclic phosphorylation-dephosphorylation cascade involving cyclin and cdc2 kinase. By constructing stability diagrams showing domains of periodic behavior as a function of the maximum rates of the kinases and phosphatases involved in the two cycles of the cascade, we investigate the role of these converter enzymes in the oscillatory mechanism. Oscillations occur when the balance of kinase and phosphatase rates in each cycle is in a range bounded by two critical values. The results suggest ways to arrest the mitotic oscillator by alteringthe maximum rates of the converter enzymes. These results bear on thecontrol of cell proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 20:48:40