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Titolo:
30 YEARS OF HUMAN PINEAL RESEARCH - DO WE KNOW ITS CLINICAL RELEVANCE
Autore:
GARCIAPATTERSON A; PUIGDOMINGO M; WEBB SM;
Indirizzi:
AUTONOMOUS UNIV BARCELONA,HOSP SANTA CRUZ & SAN PABLO,SERV ENDOCRINOL& NUTR,DEPT ENDOCRINOL E-08025 BARCELONA SPAIN AUTONOMOUS UNIV BARCELONA,HOSP SANTA CRUZ & SAN PABLO,SERV ENDOCRINOL& NUTR,DEPT ENDOCRINOL E-08025 BARCELONA SPAIN
Titolo Testata:
Journal of pineal research
fascicolo: 1, volume: 20, anno: 1996,
pagine: 1 - 6
SICI:
0742-3098(1996)20:1<1:3YOHPR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOCTURNAL MELATONIN SECRETION; INFANT-DEATH SYNDROME; BREAST-CANCER CELLS; SERUM MELATONIN; PLASMA MELATONIN; ANOREXIA-NERVOSA; CIRCADIAN-RHYTHM; PITUITARY; GROWTH; PUBERTY;
Keywords:
MELATONIN; PINEAL GLAND; HUMAN; PATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
A. Garciapatterson et al., "30 YEARS OF HUMAN PINEAL RESEARCH - DO WE KNOW ITS CLINICAL RELEVANCE", Journal of pineal research, 20(1), 1996, pp. 1-6

Abstract

A role for melatonin in humans is becoming evident in an increasing number of clinical situations. Marked variations in the magnitude of the nocturnal melatonin peak are observed throughout the human lifespan. The highest levels occur in children and then fall during puberty andfurther during adulthood. A negative correlation between circulating melatonin and sex steroids has been observed in a number of instances,and appears to be independent of concomitant gonadotrophins. No clearmelatonin pattern has been observed in pituitary tumors, but in largelesions that involve the hypothalamus, a reduced nocturnal rise has been reported. Reported effects of exogenously administered melatonin are variable, probably reflecting differences in dose and timing; a slight stimulation of prolactin, as well as a partial inhibition of gonadotrophins, has been reported, which explains its utility as an oral contraceptive, associated with a progestogen. A potential clinical use of melatonin as an oncostatic drug still awaits confirmation, although experimental data firmly support this possibility. The indole has alsobeen used to hasten entrainment of subjects travelling across varioustime zones, and has been found to be specially useful in eastward travel. Finally, changes in the normal melatonin circadian pattern have been reported in psychiatric diseases and in sudden infant death syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:01:07