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Titolo:
HUMAN FETAL HIPPOCAMPAL DEVELOPMENT .1. CYTOARCHITECTURE, MYELOARCHITECTURE, AND NEURONAL MORPHOLOGIC FEATURES
Autore:
ARNOLD SE; TROJANOWSKI JQ;
Indirizzi:
UNIV PENN,SCH MED,DEPT PSYCHIAT,142 CLIN RES BLDG,415 CURIE BLVD PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT NEUROL PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED PHILADELPHIA PA 19104
Titolo Testata:
Journal of comparative neurology
fascicolo: 2, volume: 367, anno: 1996,
pagine: 274 - 292
SICI:
0021-9967(1996)367:2<274:HFHD.C>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENTATE GRANULE CELLS; MYELIN BASIC-PROTEIN; NERVOUS-SYSTEM; RHESUS-MONKEY; MONOCLONAL-ANTIBODIES; CEREBRAL-CORTEX; TEMPORAL-LOBE; REELER MICE; MIGRATION; ORIGIN;
Keywords:
SUBICULUM; AMMONIC SUBFIELDS; DENTATE GYRUS; MYELIN BASIC PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Arnold e J.Q. Trojanowski, "HUMAN FETAL HIPPOCAMPAL DEVELOPMENT .1. CYTOARCHITECTURE, MYELOARCHITECTURE, AND NEURONAL MORPHOLOGIC FEATURES", Journal of comparative neurology, 367(2), 1996, pp. 274-292

Abstract

To characterize better the process of anatomic development of the human hippocampus, we studied the cytoarchitecture, myeloarchitecture, and neuronal morphology in human fetal and postnatal hippocampi. Twenty cases were studied in which the ages ranged form 9 weeks gestation through 62 years. Fixed, paraffin-embedded, hippocampal sections were stained with cresyl violet for Nissl substance and immunolabeleed for myelin basic protein. The hippocampal region at 9 weeks contains 4 layers: a ventricular zone, an intermediate zone, a homogeneous-appearing hippocampal plate comprised of bipolar-shaped neurons, and a wide marginal zone. At 15-19 weeks, individual subfields can be distinguished. A distal-to-proximal gradient of cytoarchitectural and neuronal morphologic maturity is seen, with the subiculum appearing more developed thanthe ammonic subfields and the dentate gyrus appearing least mature. Within each subfield, and ''inside-out'' gradient of maturity is also evident. By 32-34 weeks gestational age, neurons in CA2 and CA3 have undergone rapid enlargement and morphologic maturation, surpassing CA1, which still contains some immature neurons. The dentate gyrus is the latest area to develop, only assuming a mature cytoarchitecture after 34 weeks. The essential cytoarchitectural appearance of the hippocampalsubfields is stable after birth, although there is progressive neuronal enlargement and a decrease in neuronal density throughout childhoodinto adulthood. Myelination is first evident near term, with strong myelin basic protein immunoreactivity present in the angular bundle, alveus, and fimbria and relatively scant immunoreactivity in the nascentperforant pathway. Myelination in the hippocampus increases in childhood until adolescence, after which the pattern remains unchanged. These studies delineate normal neuroanatomic development and can be used to understand better the mechanisms underlying human neurodevelopmentaland neurodegenerative disorders of the hippocampal formation. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:39:36