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Titolo:
D1 DOPAMINE RECEPTOR-MEDIATED INDUCTION OF ZIF268 AND C-FOS IN THE DOPAMINE-DEPLETED STRIATUM - DIFFERENTIAL REGULATION AND INDEPENDENCE FROM NMDA RECEPTORS
Autore:
KEEFE KA; GERFEN CR;
Indirizzi:
NIMH,NEUROPHYSIOL LAB,BLDG 36,ROOM 2D-10 BETHESDA MD 20892 NIMH,NEUROPHYSIOL LAB BETHESDA MD 20892
Titolo Testata:
Journal of comparative neurology
fascicolo: 2, volume: 367, anno: 1996,
pagine: 165 - 176
SICI:
0021-9967(1996)367:2<165:DDRIOZ>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFIED STRIATONIGRAL NEURONS; SUBSTANTIA-NIGRA; TYROSINE-HYDROXYLASE; GENE-EXPRESSION; STRIATOPALLIDAL NEURONS; EXTRACELLULAR DOPAMINE; NUCLEUS-ACCUMBENS; DENDRITIC SPINES; CORTICAL INPUTS; FACTOR CREB;
Keywords:
IN SITU HYBRIDIZATION; C-FOS; ZIF268; GLUTAMATE ANTAGONISTS; SKF 38393;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Keefe e C.R. Gerfen, "D1 DOPAMINE RECEPTOR-MEDIATED INDUCTION OF ZIF268 AND C-FOS IN THE DOPAMINE-DEPLETED STRIATUM - DIFFERENTIAL REGULATION AND INDEPENDENCE FROM NMDA RECEPTORS", Journal of comparative neurology, 367(2), 1996, pp. 165-176

Abstract

Excitatory amino acid afferents from cerebral cortex and dopamine afferents from the substantia nigra synapse on common projection neurons in the striatum. Activation of D1 dopamine receptors increases immediate early gene expression in the striatum and conductance through the N-methyl-d-aspartate (NMDA) receptor. To examine the contribution of NMDA receptor activation to dopamine receptor-mediated responses, we determined the effects of intrastriatal administration of NMDA antagonists on immediate early gene expression in the striatum and rotational behavior induced by stimulation of the D1 receptor in rats with unilateral dopamine depletions. Systemic administration of SKF 38393 increasedc-fos and zif268 mRNAs in the striatum and induced contralateral rotation. Intrastriatal infusion of the competitive NMDA receptor antagonist -)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid caused a dose-dependent attenuation of SKF 38393-induced rotation and partially decreased c-fos mRNA expression. However, D1-mediated increases in zif268 mRNA were not affected, except by the highest concentration of antagonist used (10 mM). Another competitive antagonist, 2-amino-5-phosphonovaleric acid, had similar effects. Like the competitive antagonists,intrastriatal infusion of the non-competitive NMDA antagonist MK-801 partially decreased c-fos, but not zif268, mRNA in the area around themicrodialysis probe. However, unlike competitive antagonists, local infusion of 1 mM MK-801 potentiated D1-mediated increases in c-fos and zif268 mRNAs in lateral striatum. These data suggest that 1) some D1 dopamine receptor-mediated effects on striatal function are independentof ongoing NMDA receptor activation, whereas other effects are at least partially mediated by NMDA receptor activity in the striatum, and 2) competitive and non-competitive antagonists of the NMDA receptor differently affect D1-mediated immediate early gene expression in the striatum. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:55:03