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Titolo:
ARTERIAL STIFFNESS, HYDROCHLOROTHIAZIDE AND CONVERTING-ENZYME INHIBITION IN ESSENTIAL-HYPERTENSION
Autore:
BENETOS A; LAFLECHE A; ASMAR R; GAUTIER S; SAFAR A; SAFAR ME;
Indirizzi:
HOP BROUSSAIS,SERV MED 1,96 RUE DIDOT F-75674 PARIS FRANCE HOP BROUSSAIS,DEPT INTERNAL MED F-75674 PARIS FRANCE
Titolo Testata:
Journal of human hypertension
fascicolo: 2, volume: 10, anno: 1996,
pagine: 77 - 82
SICI:
0950-9240(1996)10:2<77:ASHACI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTENSIBILITY; DIAMETER; PRESSURE;
Keywords:
HYPERTENSION; ARTERIAL SYSTEM; DIURETIC COMPOUNDS; CONVERTING ENZYME INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A. Benetos et al., "ARTERIAL STIFFNESS, HYDROCHLOROTHIAZIDE AND CONVERTING-ENZYME INHIBITION IN ESSENTIAL-HYPERTENSION", Journal of human hypertension, 10(2), 1996, pp. 77-82

Abstract

In a randomized double blind study, the arterial changes produced either by hydrochlorothiazide plus amiloride (Group I), or by hydrochlorothiazide plus captopril (Group II) were investigated in two territories of the arterial tree, the common carotid artery and the terminal aorta. Arterial echo-tracking techniques of high resolution and applanation tonometry were used to evaluate non-invasively the indices of arterial stiffness and carotid wave reflections. In Groups I and II, there was a similar significant decrease in brachial blood pressure (BP) andcarotid diastolic diameter and an increase in aortic compliance and distensibility. Groups I and II differed significantly in aortic diastolic diameter which decreased in Group I but not in Group II, and in carotid wave reflections which were modified in Group II but not in Group I. Thus, captopril associated with hydrochlorothiazide resulted in ashift in the carotid arterial reflection wave from systole to diastole with no reduction in the aortic diastolic dimension. For similar BP reduction, the combination of hydrochlorothiazide and amiloride had nosignificant effect on the carotid reflection wave, but caused a significant reduction in the aortic diastolic diameter. These intergroup differences were related to the presence or absence of converting enzymeinhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:24:14