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Titolo:
STRESS THROUGH HANDLING FOR VAGINAL SCREENING, SEROTONIN, AND ACTH RESPONSE TO ETHER
Autore:
SFIKAKIS A; GALANOPOULOU P; KONSTANDI M; TSAKAYANNIS D;
Indirizzi:
UNIV ATHENS,SCH MED,DEPT EXPTL PHARMACOL,76 M ASIS STR GR-11527 ATHENS GREECE
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 53, anno: 1996,
pagine: 965 - 970
SICI:
0091-3057(1996)53:4<965:STHFVS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; RAT HYPOTHALAMUS INVITRO; PITUITARY CYCLIC-AMP; ESTROUS-CYCLE; FEMALE RATS; SECRETION; CORTICOSTERONE; ADRENOCORTICOTROPIN; PROLACTIN; SYSTEM;
Keywords:
HANDLING FOR VAGINAL SMEAR SCREENING; DURATION; RESISTANCE; ADRENAL WEIGHT; ACTH; ETHER STRESS; DIESTRUS-2; HYPOTHALAMIC 5-HT; 5-HIAA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Sfikakis et al., "STRESS THROUGH HANDLING FOR VAGINAL SCREENING, SEROTONIN, AND ACTH RESPONSE TO ETHER", Pharmacology, biochemistry and behavior, 53(4), 1996, pp. 965-970

Abstract

The effect of duration of handling for vaginal smear screening on theadrenal weight and acute ACTH response to ether were examined in 4-day-cycling female rats, sacrificed at 97-103 days of age on diestrus-2 after evaluation of resistance to handling, thymus weight, and hypothalamic serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). Prolonged handling paralleled increased resistance (behavioral response) to handling and adrenal weight but was inversely related to thymus weight. The hypothalamic 5-HT, 5-HIAA, and 5-HIAA/5-HT ratio, compared to controls with similar conditions of handling, were not modified after 2.5 min of ether despite the ACTH rise. In ether-stressed rats, the ACTHresponse to ether was lower after prolonged handling compared to short handling paralleling decreased thymus weight. In contrast, 5-HT, 5-HIAA, and the 5-HIAA/5-HT ratio were higher, paralleling increased resistance and adrenal weight. The results suggest chronic activation of the hypothalamo-pituitary-adrenal axis with positive serotonergic involvement after prolonged handling and resistance during vaginal screening and a negative implication of this activation on the acute ACTH response to ether.

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Documento generato il 26/09/20 alle ore 23:39:39