Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SEROTONERGIC ACTIVATION REDUCES DEFENSIVE FREEZING IN THE CONDITIONEDFEAR PARADIGM
Autore:
INOUE T; TSUCHIYA K; KOYAMA T;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PSYCHIAT,KITA KU,N 15,W 7 SAPPORO HOKKAIDO060 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 53, anno: 1996,
pagine: 825 - 831
SICI:
0091-3057(1996)53:4<825:SARDFI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODELS; UPTAKE INHIBITOR; ANXIETY DISORDERS; RECEPTOR AGONISTS; 5-HT1A RECEPTORS; PANIC DISORDER; RAT-BRAIN; IPSAPIRONE; BUSPIRONE; STRESS;
Keywords:
SEROTONIN; CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; ANXIETY; ANXIOLYTIC; IPSAPIRONE; CITALOPRAM; 5-HT1A RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
T. Inoue et al., "SEROTONERGIC ACTIVATION REDUCES DEFENSIVE FREEZING IN THE CONDITIONEDFEAR PARADIGM", Pharmacology, biochemistry and behavior, 53(4), 1996, pp. 825-831

Abstract

Our previous study showed that conditioned fear stress (CFS) increased serotonin (5-HT) metabolism in the medial prefrontal cortex and induced freezing behavior. Although these results could support the 5-HT hypothesis of anxiety, the functional significance of the 5-HT responseto stress is unclear. In this study, the effects of 5-HT reuptake inhibitors, agonists, antagonists, and diazepam on freezing behavior induced by CFS were examined using a time-sampling procedure. Various doses of test compounds were administered subcutaneously to rats 24 h after the last session of repeated foot-shock for 5 days. Rats were again placed in the shock chamber without shocks 20 min after injections of drugs, and observed. Diazepam (1 mg/kg) and the 5-HT1A agonist ipsapirone (0.5-10 mg/kg) significantly inhibited Freezing behavior. L-5-Hydroxytryptophan (with benserazide) and the selective 5-HT reuptake inhibitor citalopram (10 mg/kg) reduced freezing behavior. The 5-HT2 antagonists ICI169,369 and ketanserin Failed to change freezing behavior. p-Chlorophenylalanine (200 mg/kg) administered 15 h before the test did not affect freezing. The effect of ipsapirone was not modified in ratswith lesions of 5-HT neurons, produced by p-chloroamphetamine (2 x 10mg/kg). In conclusion, these results suggest the anxiolytic potentialof ipsapirone and citalopram, and support the hypothesis that the facilitation of 5-HT neurotransmission decreases anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:56:32