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Titolo:
CLINICAL INDICATORS OF GENETIC SUSCEPTIBILITY TO EPILEPSY
Autore:
OTTMAN R; LEE JH; RISCH N; HAUSER WA; SUSSER M;
Indirizzi:
COLUMBIA UNIV,GH SERGIEVSKY CTR,SCH PUBL HLTH,630 W 168TH ST NEW YORKNY 10032 COLUMBIA UNIV,DIV EPIDEMIOL,SCH PUBL HLTH NEW YORK NY 10032 COLUMBIA UNIV,DEPT NEUROL NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,EPIDEMIOL BRAIN DISORDERS RES DEPT NEW YORK NY 00000 STANFORD UNIV,SCH MED,DEPT GENET STANFORD CA 94305
Titolo Testata:
Epilepsia
fascicolo: 4, volume: 37, anno: 1996,
pagine: 353 - 361
SICI:
0013-9580(1996)37:4<353:CIOGST>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURE DISORDERS; CLASSIFICATION; ABNORMALITIES; CHILDHOOD; ROCHESTER; MINNESOTA; FAMILY; RISK;
Keywords:
EPILEPSY; SEIZURES; EPIDEMIOLOGY; HUMAN GENETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R. Ottman et al., "CLINICAL INDICATORS OF GENETIC SUSCEPTIBILITY TO EPILEPSY", Epilepsia, 37(4), 1996, pp. 353-361

Abstract

We evaluated clinical indicators of genetic susceptibility to epilepsy in the families of 1,957 adults with epilepsy (probands) ascertainedfrom voluntary organizations. Very few of the probands in this serieshad idiopathic epilepsy syndromes. Among relatives of probands with postnatal CNS insults, risks of epilepsy were no higher than in the general population. Risk was increased in relatives of probands without identified CNS insults (i.e., those with idiopathic/cryptogenic epilepsy) or with neurological deficit presumed present at birth, compared with relatives of probands with postnatal CNS insults, Among relatives of probands with idiopathic/cryptogenic epilepsy, risks were higher in parents and siblings, but not in offspring, of probands with generalized onset as compared with partial onset seizures. Risks in offspring were higher if the probands had onset of idiopathic/cryptogenic epilepsy before age 10 as compared with age greater than or equal to 10 years, but risks in parents and siblings were not associated with the proband's age at onset. These results suggest that genetic susceptibility increases risk of some forms of cryptogenic epilepsy and of epilepsy associated with neurological deficit presumed present at birth, but not of postnatal symptomatic epilepsy. The influences on risk in offspringmay differ from those in parents and siblings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:16:06