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Titolo:
PHYSIOLOGY AND BIOCHEMISTRY OF THE KIDNEY VACUOLAR H-ATPASE()
Autore:
GLUCK SL; UNDERHILL DM; IYORI M; HOLLIDAY LS; KOSTROMINOVA TY; LEE BS;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT MED ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT CELL BIOL & PHYSIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,GEORGE M OBRIEN KIDNEY & UROL DIS CTR ST LOUIS MO 63110
Titolo Testata:
Annual review of physiology
, volume: 58, anno: 1996,
pagine: 427 - 445
SICI:
0066-4278(1996)58:<427:PABOTK>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY COLLECTING DUCT; ETHYLMALEIMIDE-SENSITIVE ATPASE; RENAL BICARBONATE REABSORPTION; THICK ASCENDING LIMB; TRANSLOCATING ADENOSINE-TRIPHOSPHATASE; COATED VESICLE (H+)-ATPASE; DISTAL NEPHRON SEGMENTS; INTERCALATED CELLS; PROTON PUMP; METABOLIC-ACIDOSIS;
Keywords:
URINARY ACIDIFICATION; H+ TRANSPORT; COLLECTING TUBULE; PROXIMAL TUBULE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
127
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Gluck et al., "PHYSIOLOGY AND BIOCHEMISTRY OF THE KIDNEY VACUOLAR H-ATPASE()", Annual review of physiology, 58, 1996, pp. 427-445

Abstract

Vacuolar H+-ATPases have an essential role in renal hydrogen ion secretion in the proximal tubule, collecting duct, and other segments of the nephron. Control of H+ transport is achieved by variations in the intrinsic properties of the renal H+-ATPases and by several cellular regulatory mechanisms, including redistribution of the enzyme both by vesicular traffic and regulated assembly and disassembly, and cytosolic regulatory proteins that interact directly with H+-ATPase. These mechanisms may provide a means for fine control of net acid excretion and for regulating vacuolar H+-ATPases residing on the plasma membrane independently from those in intracellular compartments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:40:15