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Titolo:
THE TREFOIL PEPTIDE FAMILY
Autore:
SANDS BE; PODOLSKY DK;
Indirizzi:
MASSACHUSETTS GEN HOSP,GASTROINTESTINAL UNIT BOSTON MA 02114 MASSACHUSETTS GEN HOSP,CTR STUDY INFLAMMATORY BOWEL DIS BOSTON MA 02114 HARVARD UNIV,SCH MED BOSTON MA 02114
Titolo Testata:
Annual review of physiology
, volume: 58, anno: 1996,
pagine: 253 - 273
SICI:
0066-4278(1996)58:<253:TTPF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST-CANCER; PANCREATIC SPASMOLYTIC POLYPEPTIDE; EPIDERMAL GROWTH-FACTOR; CELL-LINE MCF-7; AMINO-ACID-SEQUENCE; XENOPUS-LAEVIS SKIN; RESPONSIVE GENE PS2; MESSENGER-RNA; P-DOMAIN; INTEGUMENTARY MUCIN;
Keywords:
ITF; PS2; SPASMOLYTIC POLYPEPTIDE; MUCIN GLYCOPROTEIN; WOUND HEALING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
B.E. Sands e D.K. Podolsky, "THE TREFOIL PEPTIDE FAMILY", Annual review of physiology, 58, 1996, pp. 253-273

Abstract

The unique three-loop structure of the trefoil motif, formed by intrachain disulfide bonds in a 1-5, 2-4, 3-6 configuration between six conserved cysteine residues, is the defining feature of a recently recognized family of peptides. Expression of trefoil peptides is closely related to that of mucin glycoproteins in diverse biological sources. Three distinct members of the family (pS2, intestinal trefoil factor, andspasmolytic polypeptide) are produced in the mammalian gastrointestinal tract by mucus-secreting cells and targeted primarily for luminal secretion. The compact structure of the trefoil motif may be responsible for marked resistance of trefoil peptides to proteolytic digestion, enabling them to function in the harsh environment of the gastrointestinal lumen. Trefoil peptides are ectopically expressed adjacent to areas of inflammation within the gastrointestinal tract and may play an important role in both maintaining the barrier function of mucosal surfaces and facilitating healing after injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:13:27