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Titolo:
THE HUMAN LEUKOTRIENE A(4) HYDROLASE GENE IS EXPRESSED IN 2 ALTERNATIVELY SPLICED MESSENGER-RNA FORMS
Autore:
JENDRASCHAK E; KAMINSKI WE; KIEFL R; VONSCHACKY C;
Indirizzi:
WASHINGTON UNIV,DEPT BIOL STRUCT,SCH MED,BOX 357420 SEATTLE WA 98195 UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN D-80336 MUNICH GERMANY
Titolo Testata:
Biochemical journal
, volume: 314, anno: 1996,
parte:, 3
pagine: 733 - 737
SICI:
0264-6021(1996)314:<733:THLAHG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONONUCLEAR-CELLS; FACTOR MESSENGER-RNA; N-3 FATTY-ACIDS; MOLECULAR-CLONING; HUMAN-ERYTHROCYTES; EPOXIDE HYDROLASE; AMINOPEPTIDASE; PURIFICATION; CATABOLISM; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
E. Jendraschak et al., "THE HUMAN LEUKOTRIENE A(4) HYDROLASE GENE IS EXPRESSED IN 2 ALTERNATIVELY SPLICED MESSENGER-RNA FORMS", Biochemical journal, 314, 1996, pp. 733-737

Abstract

We identified a novel short (s-) mRNA of the human leukotriene-A(4) (LTA(4)) hydrolase using sequential reverse transcriptase PCR mapping. The s-mRNA is generated by skipping an 83 bp exon located in the 3' coding region and suggests the expression of an LTA, hydrolase isoform with a calculated molecular mass of 59 kDa and a distinct C-terminus. Both LTA(4) hydrolase mRNAs are constitutively expressed in blood cells, endothelial cells, smooth muscle cells, fibroblasts and tumour cells. The ratios of their mRNA expression levels are cell specific, with relatively high s-form mRNA expression in reticulocytes. Our data strongly suggest that the novel mRNA codes for the structurally related butdistinct LTA(4) hydrolase isoenzyme that has been postulated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:00:04