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Titolo:
BEHAVIORAL-STUDIES ON ALKALOIDS EXTRACTED FROM THE LEAVES OF HUNTERIA-ZEYLANICA
Autore:
LEEWANICH P; TOHDA M; MATSUMOTO K; SUBHADHIRASAKUL S; TAKAYAMA H; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DIV PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DIV PHARMACOL TOYAMA 93001 JAPAN PRINCE SONGKLA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT BOT & PHARMACOGNOSY SONGKHLA 90112 THAILAND CHIBA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT CHEM CHIBA 263 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 3, volume: 19, anno: 1996,
pagine: 394 - 399
SICI:
0918-6158(1996)19:3<394:BOAEFT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE; ANXIETY; PROCONVULSANT; PRIMATES; LIGAND;
Keywords:
HUNTERIA ZEYLANICA; LOCOMOTOR ACTIVITY; REARING; PENTOBARBITAL-INDUCED SLEEP; DRUG-INDUCED CONVULSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
P. Leewanich et al., "BEHAVIORAL-STUDIES ON ALKALOIDS EXTRACTED FROM THE LEAVES OF HUNTERIA-ZEYLANICA", Biological & pharmaceutical bulletin, 19(3), 1996, pp. 394-399

Abstract

The effects of a crude methanol extract, butanol- and chloroform-fractions, and a pure compound, corymine, extracted from the leaves of H. zeylanica on locomotor activity and rearing, pentobarbital-induced sleep, and drug-induced convulsions were studied in mice. The methanol extract dose-dependently decreased rearing,without a significant effect on locomotor activity at doses of 15, 60 and 120 mg/kg. It did not significantly prolong the sleeping time but potentiated the convulsions induced by strychnine, but not that by either picrotoxin or pentylenetetrazole, at a dose of 120 mg/kg. The butanol-fraction significantly prolonged sleeping time at a dose of 125 mg/kg but did not affect eitherof the convulsive drugs. The chloroform fraction prolonged sleeping time at doses of 62.5 and 125 mg/kg and potentiated the convulsions induced by either strychnine or picrotoxin, but not that by pentylenetetrazole, at doses of 15, 30, 60 and 120 mg/kg. Corymine did not significantly prolong sleeping time, but potentiated the convulsions induced by either strychnine or picrotoxin, not by pentylenetetrazole, at dosesof 2, 8 and 15 mg/kg. These results suggest that crude alkaloidal extracts of H. zeylanica leaves produce biphasic effects on the central nervous system (CNS), depression and stimulation, while the pure compound, corymine, has a unique central stimulatory effect in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:29:59