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Titolo:
PTX-SENSITIVE REGULATION OF NEURITE OUTGROWTH BY THE DOPAMINE D-3 RECEPTOR
Autore:
SWARZENSKI BC; OMALLEY KL; TODD RD;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,BOX 8134,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL ST LOUIS MO 63110
Titolo Testata:
NeuroReport
fascicolo: 2, volume: 7, anno: 1996,
pagine: 573 - 576
SICI:
0959-4965(1996)7:2<573:PRONOB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS;
Keywords:
DOPAMINE D-3 RECEPTOR; MESENCEPHALIC CELL LINE; NEURITE OUTGROWTH; G-PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Swarzenski et al., "PTX-SENSITIVE REGULATION OF NEURITE OUTGROWTH BY THE DOPAMINE D-3 RECEPTOR", NeuroReport, 7(2), 1996, pp. 573-576

Abstract

NEUROTRANSMITTER receptors are known to have direct roles in the modulation of neuronal morphogenesis. Previous work showed that clonal mesencephalic MN9D cells individually transfected with D-2-like dopamine receptors show increased neurite outgrowth following long-term exposure to the D-2-like receptor agonist quinpirole. In the current study, brief stimulation of D-3 receptor-expressing cells also elicited increased neurite outgrowth, which could be mimicked by the G(i)/G(o) protein activator mastoparan. Pretreatment with the G(i)/G(o) protein inhibitor pertussis-toxin blocked the quinpirole- and mastoparan-mediated increases in outgrowth. These results suggest that dopamine D-3 receptorstimulation has an immediate, G-protein-mediated role in neuronal morphogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:52:46