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Titolo:
INVOLVEMENT OF THE PRESYNAPTIC DOPAMINE D2 RECEPTOR IN THE DEPRESSIONOF SPINAL REFLEX BY APOMORPHINE
Autore:
GAJENDIRAN M; SETH P; GANGULY DK;
Indirizzi:
INDIAN INST CHEM BIOL,DIV PHARMACOL & EXPTL THERAPEUT,4 RAJA SC MULLICK RD CALCUTTA 700032 W BENGAL INDIA INDIAN INST CHEM BIOL,DIV PHARMACOL & EXPTL THERAPEUT CALCUTTA 700032W BENGAL INDIA
Titolo Testata:
NeuroReport
fascicolo: 2, volume: 7, anno: 1996,
pagine: 513 - 516
SICI:
0959-4965(1996)7:2<513:IOTPDD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC TRANSMISSION; RENSHAW CELLS; RAT; CORD; HALOPERIDOL; MODULATION; SPIPERONE; SEDATION; BLOCKADE; RELEASE;
Keywords:
DOPAMINE RECEPTORS; APOMORPHINE; SPIPERONE; SKF 38393; SCH 23390; SPINAL REFLEX; PRESYNAPTIC; SPINAL CORD; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Gajendiran et al., "INVOLVEMENT OF THE PRESYNAPTIC DOPAMINE D2 RECEPTOR IN THE DEPRESSIONOF SPINAL REFLEX BY APOMORPHINE", NeuroReport, 7(2), 1996, pp. 513-516

Abstract

THE relative roles of D1 and D2 dopamine (DA) receptors in mediating apomorphine (APO)-induced changes in the spinal reflex was investigated. Low doses of APO, a DA receptor agonist (0.2 mg kg(-1), i.v.), depressed the monosynaptic mass (MMR) in spinalized rats. Pretreatment with D2-specific antagonist, spiperone, 10 min before APO prevented the APO-induced MMR depression. Pretreatment with the D1 antagonist SCH 23390 failed to prevent the APO-induced depression. Interestingly, SCH 23390 pretreatment preferentially antagonized the depression induced by a high dose of APO (3 mg kg(-1), i.v.). Pretreatment with SKF 38393, aselective D1 agonist, completely prevented the APO-induced MMR depression. These results suggest that inhibition of spinal transmission by low dose of APO may be mediated through its action on presynaptic D2 receptors and that D1 and D2 receptors are functionally coupled at the spinal level in modulating the spinal motor output.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:46:35