Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARISON OF BIOCHEMICAL INDEXES FOR ASSESSING VITAMIN-K NUTRITIONAL-STATUS IN A HEALTHY ADULT-POPULATION
Autore:
SOKOLL LJ; SADOWSKI JA;
Indirizzi:
TUFTS UNIV,USDA,JEAN MAYER HUMAN NUTR RES CTR AGING,711 WASHINGTON STBOSTON MA 02111 TUFTS UNIV,USDA,JEAN MAYER HUMAN NUTR RES CTR AGING BOSTON MA 02111
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 4, volume: 63, anno: 1996,
pagine: 566 - 573
SICI:
0002-9165(1996)63:4<566:COBIFA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE GLA-PROTEIN; GAMMA-CARBOXYGLUTAMIC ACID; URINARY CALCIUM EXCRETION; AGE-RELATED-CHANGES; SERUM OSTEOCALCIN; CIRCULATING OSTEOCALCIN; PLASMA OSTEOCALCIN; PAGETS-DISEASE; ELDERLY WOMEN; SEX;
Keywords:
VITAMIN-K; OSTEOCALCIN; PHYLLOQUINONE; GAMMA-CARBOXYGLUTAMIC ACID; PIVKA-II; AGING; NUTRITIONAL STATUS; UNDERCARBOXYLATED PROTHROMBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
L.J. Sokoll e J.A. Sadowski, "COMPARISON OF BIOCHEMICAL INDEXES FOR ASSESSING VITAMIN-K NUTRITIONAL-STATUS IN A HEALTHY ADULT-POPULATION", The American journal of clinical nutrition, 63(4), 1996, pp. 566-573

Abstract

Biochemical indexes for assessing vitamin K nutritional status were evaluated in 263 healthy subjects (127 males, 136 females) aged 18-85 y. The influences of aging (stratified by decade), menopause, and sex were examined. Total, carboxylated, and undercarboxylated osteocalcin concentrations were affected by sex and aging with increases in the sixth decade in women attributed to menopause. Aging effects in the womenand sex differences were eliminated when undercarboxylated osteocalcin was expressed as a percentage of the total. Plasma phylloquinone andundercarboxylated prothrombin (PIVKA-II) concentrations varied Littlewith aging with the exception of lower concentrations of phylloquinone in women in their third decade compared with other ages and higher concentrations of PIVKA-II in younger males compared with younger females. Urinary gamma-carboxyglutamic acid (Gla)-creatinine excretion ratios increased significantly with age in both males (r = 0.68, P < 0.001) and females (r = 0.63, P < 0.001) with values 20% higher in the females on average over the entire age span. The undercarboxylated osteocalcin concentration, shown previously to be responsive to depletion andrepletion of phylloquinone, was compared with the other indexes to determine its reliability as an indicator of vitamin K nutritional status. This measure appears promising because it correlated with plasma PIVKA-II concentrations (r = 0.27, P < 0.001) and with plasma phylloquinone concentrations (r = -0.35, P < 0.001), whereas the agreement between plasma phylloquinone and PIVKA-II concentrations was not as strong (r = -0.15, P < 0.05).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:55:02